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1385/10/10، جلد ۵، شماره ۴، صفحات -
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
HTLV-I Infection: Virus structure, Immune Response to the Virus and Genetic Association Studies in HTLV-I-Infected Individuals |
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| چکیده انگلیسی مقاله |
Although the structure of human T lymphoptropic virus type I (HTLV-I) has been known well, the function of some proteins encoded by HTLV-I PX region is not fully understood. Furthermore, the responses of the immune system to HTLV-I remain still unknown. Most of HTLV-I-infected individuals show a strong and persistently activated cytotoxic T-cell (CTL) response to the virus. The frequency of HTLV-I specific CTL is higher in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) compared with HTLV-I carriers. However, the efficacy of the immune response determines the outcome of HTLV-I-associated diseases. Among the risk factors which contribute to the observed differences between HAM/TSP patients and HTLV-I carriers, the interaction between different genes and/or environmental factors seem to be important. These factors may also involve in outcome of HTLV-I infection in infected-individuals. |
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| کلیدواژههای انگلیسی مقاله |
CTL response, Cytokine gene polymorphism, HAM/TSP, HTLV-I, MHC |
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| نویسندگان مقاله |
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| نشانی اینترنتی |
http://ijaai.tums.ac.ir/index.php/ijaai/article/viewArticle/149 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Articles |
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