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1392/6/6، جلد ۱۲، شماره ۴، صفحات -
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
IL-13 Gene Polymorphisms and Their Association with Atopic Asthma and Rhinitis in Pakistani Patients |
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| چکیده انگلیسی مقاله |
Interleukin-13 (IL-13) is known to be a key regulator in immunoglobulin E (IgE) synthesis, mucus hypersecretion and airway hyperresponsiveness. Single nucleotide polymorphisms in IL-13 are associated with allergic phenotypes in several ethnically diverse populations. This study was performed in 214 atopic patients (asthma n=108, allergic rhinitis n=106) and sex-matched healthy controls (n=120). Genotyping of IL-13 gene polymorphisms was performed using polymerase chain reaction-based restriction fragment length polymorphism method. A statistically significant association of the A-1512C polymorphism in IL13 gene was observed with atopy ( p <0.001; χ 2 =19.0). Upon stratification of the data into asthma and AR association was revealed with both asthma ( p= 0.01; χ 2 =8.80) and AR ( p <0.001; χ 2 =24.3) in Pakistani patients. Higher odds ratio (OR 95% CI) was observed for AR 3.42 (2.04-5.76) relative to asthma 2.40 (1.41-4.09) for the C allele compared to controls. In conclusion the study provides the evidence A-1512C polymorphisms in IL-13 is a risk factor for asthma and AR. |
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| کلیدواژههای انگلیسی مقاله |
Allergic rhinitis(AR); Atopic asthma; Interleukin-13 (IL-13); Polymorphism |
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| نویسندگان مقاله |
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| نشانی اینترنتی |
http://ijaai.tums.ac.ir/index.php/ijaai/article/viewArticle/564 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Articles |
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