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1392/12/9، جلد ۱۳، شماره ۱، صفحات -
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
Rosiglitazone Inhibits HMC-1 Cell Migration and Adhesion Through a Peroxisome Proliferator-Activated Receptor Gamma-Dependent Mechanism |
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| چکیده انگلیسی مقاله |
Mast cells play an important role in a variety of inflammatory diseases, particularly asthma and atopy. Peroxisome proliferator-activated receptor gamma (PPARγ) is a member of the large nuclear hormone receptor transcription factor superfamily, and has been recently implicated in the anti-inflammatory response. To investigate a possible role for PPARγ in human mast cells, we studied the effects of a PPARγ ligand, rosiglitazone (RG), on stem cell factor (SCF)-induced migration and fibronectin-induced adhesion in human mast cell-1(HMC-1) cells. It was found that HMC-1 cells expressed PPARγ mRNA. RG inhibited SCF-induced HMC-1 cell migration and fibronectin-induced HMC-1 cell adhesion, the selective PPARγ antagonist GW9662 prevented the inhibitory effect of RG on HMC-1 cells. In conclusion, RG inhibits the migration and adhesion of HMC-1 cells by a PPARγ-dependent mechanism. |
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| کلیدواژههای انگلیسی مقاله |
Adhesion; Mast cells; Migration; PPARγ; Rosiglitazone |
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| نویسندگان مقاله |
43268---43269---43270---43271---43272--- |
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| نشانی اینترنتی |
http://ijaai.tums.ac.ir/index.php/ijaai/article/viewArticle/645 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Articles |
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