1391/8/7، جلد ۱۱، شماره ۳، صفحات -
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Association of Single Nucleotide Polymorphisms in the Human Tumor Necrosis Factor-α and Interleukin 1-β Genes in Patients with Pre-eclampsia
چکیده انگلیسی مقاله Pre-eclampsia is a pregnancy-specific syndrome that may be dangerous especially to the fetus. Different cytokines have been found to be elevated in women with pre-eclampsia and may have possible roles in the development of this disorder. Alleles of the interleukin-l-beta (IL-lβ) and tumor necrosis factor alpha (TNF-α) genes are associated with pr-eeclampsia in several studies in different populations. The aim of the present study was to investigate the relationship between IL-lβ (C+3954T) and TNF-α (G-308A) gene polymorphisms with pre-eclampsia in north east of Iran (Khorasan province). This study included 54 diagnosed patients with pre-eclampsia and 50 normal pregnant women as control group. DNA was extracted from peripheral blood and the polymorphisms were determined by PCR-RFLP method. Data was analyzed using chi-square and Fisher’s exact tests. There was significant association between TNF-α (G-308A) genotype and pre-eclampsia ( p =0.001) but we did not find any significant association between IL-lβ (C+3954T) genotype and pre-eclampsia ( p =0.39). The present study might suggest a role for TNF-α in the development of pre-eclampsia; however, IL-lβ (C+3954T) polymorphism could not be considered as a marker of susceptibility to preeclampsia in our population
کلیدواژه‌های انگلیسی مقاله Gene Polymorphism; Interleukine-1 ; PCR-RFLP; Pre-eclampsia; Tumor
نویسندگان مقاله 43327---43328---43329---43330---
نشانی اینترنتی http://ijaai.tums.ac.ir/index.php/ijaai/article/viewArticle/591
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Articles
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات