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1392/4/22، جلد ۱۲، شماره ۳، صفحات -
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
Human Mesenchymal Stem Cells Elevate CD4+CD25+CD127low/- Regulatory T Cells of Asthmatic Patients via Heme Oxygenase-1 |
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| چکیده انگلیسی مقاله |
Up-regulation of CD4 + CD25 + CD127 low/- regulatory T cells (Tregs) is a new target in the treatment of asthma. Human bone marrow mesenchymal stem cells can up-regulate CD4 + CD25 + CD127 low/- regulatory T cells in vitro , meanwhile, heme oxygenase-1 (HO-1) plays an important role in the development and maintenance of CD4 + CD25 + regulatory T cells. However the mechanism has not yet been adequately understood. Hence, we wondered what effect of Heme Oxygenase-1 made on regulation of CD4 + CD25 + CD127 low/- regulatory T cells mediated by mesenchymal stem cells. Peripheral blood mononuclear cells isolated from asthmatic patients and healthy controls were co-cultured with human bone marrow mesenchymal stem cells which were pretreated with Hemin (the revulsive of Heme Oxygenase-1), Protoporphyrin Ⅸ zinc (the inhibitor of Heme Oxygenase-1) and saline. The expression of Heme Oxygenase-1 in MSCs was enhanced by Hemin and inhibited by Protoporphyrin zinc in vitro . Overexpression of Heme Oxygenase-1 elevated the proportion of CD4 + CD25 + CD127 low/- regulatory T cells in CD4 + T cells, meanwhile, inhibition of Heme Oxygenase-1 decreased the proportion of CD4 + CD25 + CD127 low/- regulatory T cells in CD4 + T cells as compared with mesenchymal stem cells alone. Taken together, these data demonstrated that Heme Oxygenase-1 contributed to the up-regulation of CD4 + CD25 + CD127 low/- regulatory T cells mediated by mesenchymal stem cells in asthma. |
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| کلیدواژههای انگلیسی مقاله |
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| نویسندگان مقاله |
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| نشانی اینترنتی |
http://ijaai.tums.ac.ir/index.php/ijaai/article/viewArticle/531 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Articles |
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