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1392/4/22، جلد ۱۲، شماره ۳، صفحات -
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
Low and High CD8 Positive T cells in Multiple Sclerosis Patients |
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| چکیده انگلیسی مقاله |
Normal 0 false false false EN-US X-NONE AR-SA Cumulating evidence points to a key role for CD8+ T cells in the pathogenesis of multiple sclerosis.CD8 expression level was believed to be present constantly on the surface of human peripheral blood T cells. However, it was shown that peripheral blood lymphocytes may be divided by the level of CD8 expression, into CD8+ high and CD8+ low T cells. Now it is well established that the CD8 low population of CD8+ T cells demonstrates an activated effector phenotype while the CD8+ high T cells have been reported to have regulatory function. In this report we used a flow cytometric assay to compare the frequency of these two subsets in multiple sclerosis patients (n=31) with healthy age- and gender-matched controls (n=18). We found that CD8+ T cells and CD8+ low T cells significantly increased in secondary progressive (SP) and primary progressive multiple sclerosis (PPMS) patients in comparison to controls ( p <0.0002 and p <0.004 respectively) and also RRMS ( p <0.005 and p <0.017 respectively). These results demonstrated the role of CD8 low T cells in progressive form of multiple sclerosis. |
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| کلیدواژههای انگلیسی مقاله |
CD8+ T cells; CD8+low T cells; CD8+high T cells; Multiple sclerosis |
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| نویسندگان مقاله |
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| نشانی اینترنتی |
http://ijaai.tums.ac.ir/index.php/ijaai/article/viewArticle/526 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Articles |
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