Background and Aim: Investigations have indicated that general health is associated with behavior style and interpersonal relationships. The present study was performed in order to investigate the relationship between general health and leadership style in managers at Shiraz University of Medical Sciences, and its effect on job satisfaction in staff.

Materials and Methods: 33 managers and 132 staff were randomly selected. Participants completed Pourbaneh leadership style, Goldberg general health and Herzberg job satisfaction questionnaires. In order to analysis data Pearson correlation coefficient, independent t test and Chi-square were used.

Results: There is a positive relationship between manager's general health and their leadership style and also between manager's leadership style and job satisfaction in staff. Also there is no significant difference between numbers of managers in 4 kinds of leadership styles.

Conclusion: Empathy, self awareness, high motivation and self confidence, are characteristics that cause positive relationship between general health and participative leadership style. These characteristics also increase self-confidence, motivation and thus increase job satisfaction in staff.