Background and Aims: n-Hexane is widely used in the production of glues, lacquers, paints, plastics, and rubber products. Consequently, a significant potential for exposure to this toxic solvent exists in industrial settings. This study was undertaken to assess the neurophysiological abnormalities in shoe-makers occupationally exposed to n-hexane and determine whether these abnormalities have any correlation with important occupational parameters.

Materials and Methods: Neurophysiological examinations of upper and lower extremities were made in 27 male-workers, and the results were compared with a sex- and age-matched reference group. In addition, the extent of exposure of individual workers and their urinary concentration of free 2,5-hexanedione were determined. Data were analyzed using the Statistical Package for Social Sciences (version 16.0. for windows).

Results: The time-weighted average exposure to n-hexane and the mean urinary concentration of free 2,5-hexanedione were both lower than the respective TLV-TWA and Biological Exposure Index (BEI) values proposed by ACGIH. Although neurological examinations and nerve conduction velocities were normal, significant negative correlations were observed between the urinary concentration of free 2,5-hexanedione and the sensory nerve action potential (SAP) amplitudes for median (r=-0.67, p<0.001) and sural (r=-0.52, p<0.008) nerves.

Conclusions: Reduced SAP amplitude for median and sural nerves appears to be the primary neurotoxic effect of 2,5-hexanedione and can be used as an appropriate indicator for screening subclinical peripheral neuropathy in n-hexane-exposed workers.