Introduction: Job satisfaction of nurses hasalwaysbeenconcernedin hospitals. It influences the quality of services offered by the nurses. Many nurses leave their job mainly due to the lack ofjob satisfaction.Different factors including the health and safety at work influencejob satisfaction. Thisstudy aimed to evaluate the occupational safety and health status of Khorram Abad’s Shohada hospital and to study its relationship with job satisfaction of nurses there.

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Material and Method: This descriptive-correlation study was carried out in Khorram Abad’s Shohada hospital. All (239)nurses working in 18wards of the hospital were participated in the study. The required data including individual and job characteristics, occupational safety and healthstatus as well as job satisfaction in terms of hospital nurses were collected using standard questionnaire. Collected data was analyzed with SPSS.19, using Kruskal-Wallis,Mann-Whitney and Spearman correlation tests.

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Result: The results showed that the occupational safety and health status of the hospital in 4 different studied areas were in a low level (with an average point of 23.2±5.3) from the participant’s point of view. The job satisfaction of nurses was also low (with an average point of 31.8±5.4). The safety and occupational health status of the hospital had a significant relationship with the nurse’s job satisfaction (P=0.001).

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Conclusion: The job satisfaction of the nurses as well as the occupational safety and health status of the hospital need to be promoted.