|
|
1391/11/14، جلد ۵، شماره ۱، صفحات -
|
|
|
| عنوان فارسی |
|
|
| چکیده فارسی مقاله |
|
|
| کلیدواژههای فارسی مقاله |
|
|
| عنوان انگلیسی |
Lower circulating levels of chemokine CXCL10 in Helicobacter pylori-infected patients with peptic ulcer: influence of the bacterial virulence factor CagA |
|
| چکیده انگلیسی مقاله |
Background and objectives : Alterations in CXCL10 (a Th1 chemokine) expression have been associated with various diseases. The aim of this study was to evaluate the serum CXCL10 levels in H. pylori -infected patients with peptic ulcer (PU) and to determine its association with bacterial virulence factor cytotoxin - associated gene A ( CagA ). Materials and Methods: Serum samples from 90 H. pylori infected patients (70 were anti- CagA + , 20 were anti- CagA - ), 65 asymptomatic (AS) carriers (40 were anti- CagA + , 25 were anti- CagA - ) and 30 healthy H. pylori -negative subjects (as a control) were tested for the concentrations of CXCL10 by using ELISA method. Results: The mean serum levels of CXCL10 in PU patients (96.64 ± 20.85 Pg/mL) was significantly lower than those observed in AS subjects (162.16 ± 53.31 Pg/mL, P < 0.01) and control group (193.93 ± 42.14 Pg/mL, P < 0.02). In the PU group, the levels of CXCL10 in anti- CagA + subjects was significantly higher in comparison to anti- CagA - patients (P<0.04). Conclusion: These results showed that the mean concentrations of CXCL10 in H. pylori -infected-PU patients was lower than AS carriers and control group. In the PU group, the serum levels of CXCL10 were affected by bacterial factor CagA . |
|
| کلیدواژههای انگلیسی مقاله |
|
|
| نویسندگان مقاله |
52102---52103---52104---52105---52106---52107---52108--- |
|
| نشانی اینترنتی |
http://ijm.tums.ac.ir/index.php/ijm/article/viewArticle/341 |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
|
| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
|
| نوع مقاله منتشر شده |
Articles |
|
|
|
برگشت به:
صفحه اول پایگاه |
نسخه مرتبط |
نشریه مرتبط |
فهرست نشریات
|
