1393/6/17، جلد ۹، شماره ۳، صفحات -

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عنوان انگلیسی Evaluation of Alum-Naltrexone Adjuvant Activity, on Efficacy of Anti-Leishmania Immunization with Autoclaved Leishmania ma¬jor (MRHO/IR/75/ER) Antigens in BALB/C Mice
چکیده انگلیسی مقاله Abstract Background: Naltrexone, an opioid receptor antagonist shifts the im­mune response toward a Th1 profile. In the current study, we evaluated the efficacy of the mixture of NTX and alum, as a new adjuvant, to en­hance immune response and induce protection against Leishmania major in a mouse model. Methods : BALB/c mice were immunized three times either autoclaved L. major promastigotes’ antigens alone or in combination with the adjuvant alum, naltrexone or the alum–naltrexone mixture. Both humoral and cellu­lar immune responses were assessed two weeks after the last immunization and compared with control mice. Results : The administration of alum- NTX in combination with the para­site antigen, significantly increased production of IFN-γ, IFN-γ /IL-5 ra­tio, lymphocyte proliferation and improved DTH response against L. ma­jor . There was no significant difference in survival following challenge among groups. Conclusion : Immunization with the alum– naltrexone mixture as an adju­vant, in combination with the autoclaved L. major promastigotes antigens, can enhance cellular immunity and shift the immune responses to a Th1 pattern. Keywords: Leishmania major , Antigen, Alum, Naltrexone, Adjuvant, BALB/c.
کلیدواژه‌های انگلیسی مقاله Keywords: Leishmania major , Antigen, Alum, Naltrexone, Adjuvant, BALB/c.

نویسندگان مقاله 53863---53864---53865---53866---53867---

نشانی اینترنتی http://ijpa.tums.ac.ir/index.php/ijpa/article/viewArticle/1302
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