1392/12/21، جلد ۹، شماره ۱، صفحات -
عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی The Effects of Babesiosis on Oxidative Stress and DNA Damage in Anatolian Black Goats Naturally Infected with Babesia ovis
چکیده انگلیسی مقاله Abstract Background: A reactive oxygen and nitrogen intermediate produced during an inflammatory response is the important part of host-defense strategies of organ­isms to kill the parasite. However, it is not well known whether these intermediates cause DNA damage and oxidative stress in goats infected with  Babesia ovis . The pur­pose of this study was to clarify the effects of babesiosis on basal levels of DNA damage and oxidative status of goats naturally infected with  B.ovis. Methods : DNA damage and antioxidant parameters were determined in B. ovis infected goats. Ten infected Anatolian Black Goats with B. ovis diagnosed via clinical signs and microscopic findings and ten healthy were used in the study. Results : The Babesia infection increased the levels of DNA damage, malondialde­hyde (MDA), protein carbonyl content (PCO) and plasma concentration of nitric oxide metabolites (NOx), and decreased total antioxidant activities (AOA) and re­duced glutathione (GSH). A significant positive correlation between DNA damage, MDA, PCO, and NOx concentrations was found in the infected goats. DNA dam­age showed a negative association with AOA and GSH concentrations in the in­fected goats. Conclusion : The Babesia infection increases oxidative stress markers and DNA damage and decreases AOA in goats. These results suggest that the increases in the production of free radicals due to Babesia infection not only contribute to host-de­fense strategies of organisms to kill the parasite but also induce oxidative damage in other cells. Keywords Babesia ovis ,  oxidative stress, DNA damage, Antioxidant activity Abstract Background: A reactive oxygen and nitrogen intermediate produced during an inflammatory response is the important part of host-defense strategies of organ­isms to kill the parasite. However, it is not well known whether these intermediates cause DNA damage and oxidative stress in goats infected with  Babesia ovis . The pur­pose of this study was to clarify the effects of babesiosis on basal levels of DNA damage and oxidative status of goats naturally infected with  B.ovis. Methods : DNA damage and antioxidant parameters were determined in B. ovis infected goats. Ten infected Anatolian Black Goats with B. ovis diagnosed via clinical signs and microscopic findings and ten healthy were used in the study. Results : The Babesia infection increased the levels of DNA damage, malondialde­hyde (MDA), protein carbonyl content (PCO) and plasma concentration of nitric oxide metabolites (NOx), and decreased total antioxidant activities (AOA) and re­duced glutathione (GSH) . A significant positive correlation between DNA damage, MDA, PCO, and NOx concentrations was found in the infected goats. DNA dam­age showed a negative association with AOA and GSH concentrations in the in­fected goats. Conclusion : The Babesia infection increases oxidative stress markers and DNA damage and decreases AOA in goats. These results suggest that the increases in the production of free radicals due to Babesia infection not only contribute to host-de­fense strategies of organisms to kill the parasite but also induce oxidative damage in other cells. Keywords Babesia ovis ,  oxidative stress, DNA damage, Antioxidant activity
کلیدواژه‌های انگلیسی مقاله Keywords Babesia ovis ,  oxidative stress, DNA damage, Antioxidant activity Abstract Background: A reactive oxygen and nitrogen intermediate produced during an inflammatory response is the important part of host-defense strategies of organ­isms to kill the parasite. However, it is not well known whether these intermediates cause DNA damage and oxidative stress in goats infected with  Babesia ovis . The pur­pose of this study was to clarify the effects of babesiosis on basal levels of DNA damage and oxidative status of goats naturally infected with  B.ovis. Methods : DNA damage and antioxidant parameters were determined in B. ovis infected goats. Ten infected Anatolian Black Goats with B. ovis diagnosed via clinical signs and microscopic findings and ten healthy were used in the study. Results : The Babesia infection increased the levels of DNA damage, malondialde­hyde (MDA), protein carbonyl cont
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نشانی اینترنتی http://ijpa.tums.ac.ir/index.php/ijpa/article/viewArticle/1016
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