| چکیده انگلیسی مقاله |
Introduction: Idiopathic facial nerve paralysis (Bell,s palsy) have been found as one of the most common form of the cranial nerve palsy. Upon our knowledge, there is not exact cause have been documented by know. currently reactivation of herpes simplex type 1have been suggested in which associated with inflammation, edema, and myelin nerve sheath destraction. To assess the efficacy of anti-inflmmatory (corticosteroids) and antiviral drugs for treating of Bell,s palsy, the present study was designed. Materials and Methods: the prospective study included patients with a diagnosis of Bell,s palsy was referred by neurology and ear, nose, throat outpatient department. Clinical and preclinical examination disclosed lack of intracranial structural lesion. Patients were randomly assigned to two groups to receive either steroids or acyclovir. The severity of facial paralysis was evaluated using the House-Brackmann classification before and after three months of the treatment. Regression to stage 1 or 2 disease was regarded as a successful response. Data were analyzed by the chi-square method and P<.0.05 was takenat-a -significant level. Results: 120 patients were treated by prednisolone (58 cases) and acyclovir (62 cases).Initial evaluation have shown that the severity of facial palsy was identical in both groups (p=0.1431). At the end of three months of treatment the results were statistically different from those of patients receiving acyclovir (p=0.0158). Moreover, the efficacy of acyclovir was more effective on improving the high grade of paralysis .There is no significant response between male or female (p=0.9456). Conclusion: although successful response was found in two treatment regimen ,but response to steroid therapy seemed to be better. Further studies with large patient series and long term follow up are needed to clarify the use of steroids or acyclovir in the treatment of idiopathic facial nerve paralysis. Keyword: Facial Nerve Paralysis, Prednisolone, Acyclovir, Recovery |
