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1392/2/9، جلد ۱۱، شماره ۳، صفحات -
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
Effects of oxcarbazepine versus carbamazepine on tinnitus: A randomized double-blind placebo-controlled clinical trial |
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| چکیده انگلیسی مقاله |
Background: It is still a challenge to find an effective treatment for tinnitus. The aim of this study was the evaluation of carbamazepine and oxcarbazepine effects on tinnitus. Methods: In a randomized double–blind clinical trial, 57 patients who were visited in a university hospital due to chronic non-pulsatile tinnitus, were randomized in three groups and treated with carbamazepine (300-600 mg/day), oxcarbazepine (450-900 mg/day) and placebo for 12 weeks. Visual analogue scale (VAS) and tinnitus severity index (TSI) were measured in all subjects in the beginning and at the end of the 8 th and 12 th weeks of the trial. Data was analyzed by repeated measure analysis, paired and independent t-test. Results: Among 51 participants who completed the trial course (28 men, 23 women), carbamazepine, oxcarbazepine and placebo decreased tinnitus severity in 56.6%, 46.2% and 38.5% of patients according to VAS, and in 61.1%, 58.8% and 50% of patients according to TSI, respectively. The effects of carbamazepine and oxcarbazepine were better in the first 8 weeks of treatment. However, their effect on tinnitus did not show any statistical difference in comparison with placebo (P = 0.34, P = 0.28). Conclusion: Carbamazepine and oxcarbazepine are not more effective than placebo in decreasing tinnitus severity. Keywords: Tinnitus, Anticonvulsants, Carbamazepine, Oxcarbazepine |
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| کلیدواژههای انگلیسی مقاله |
Keywords: Tinnitus, Anticonvulsants, Carbamazepine, Oxcarbazepine |
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| نویسندگان مقاله |
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| نشانی اینترنتی |
http://ijnl.tums.ac.ir/index.php/ijnl/article/viewArticle/116 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original Article(s) |
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