1392/4/11، جلد ۱۲، شماره ۲، صفحات -
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عنوان انگلیسی Is serum vitamin D levels associated with disability in patients with newly diagnosed multiple sclerosis?
چکیده انگلیسی مقاله Abstract Background: Although the precise etiology of multiple sclerosis (MS) is unknown, it seems that both genetic and environmental factors are important. Recent studies suggest that low serum vitamin D levels are important environmental factor in MS. The aim of this study was to compare the serum levels of vitamin D between MS patients and healthy subjects, and to determine its association with disability in MS patients. Methods: In this cross-sectional study, a total of 52 patients with MS were randomly recruited and matched for age and sex with 52 healthy subjects. Demographic characteristics and serum vitamin D levels for both groups, as well as duration of disease Expanded Disability Status Scale (EDSS) for MS patients were evaluated. Statistical analysis was performed by independent samples t-test and multiple linear regression analysis. Results: The mean serum vitamin D levels were 26.5 ± 16.3 ng/ml in MS patients vs. 37.1 ±19.7 in healthy subjects (P = 0.003). A linear regression analysis showed no significant association between vitamin D levels and EDSS score of patients with MS (P = 0.345), after adjusting for the covariates. Conclusion: Our findings did not suggest a protective association for serum vitamin D levels against disability in MS patients. Methods: In this comparative cross-sectional study, a total of 52 patients with MS were randomly recruited and matched for age and sex with 52 healthy subjects. Demographic characteristics and serum vitamin D levels for both groups, as well as duration of disease Expanded Disability Status Scale (EDSS) for MS patients were evaluated. Statistical analysis was performed by independent samples t-test and multiple linear regression analysis. Results: The mean serum vitamin D levels were 26.50±16.33 ng/ml in MS patients vs. 37.14±19.69 in healthy subjects (P< 0.003). A linear regression analysis showed no significant association between vitamin D levels and EDSS score of patients with MS (P= 0.345), after adjusting for the covariates. Conclusion: Our findings did not suggest a protective association between serum vitamin D levels and disability in MS patients. Key words : Multiple sclerosis, Vitamin D, 25-hydroxyvitamin D , Deficiency
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نویسندگان مقاله 55721---55722---55723---55724---55725---55726---55727---
نشانی اینترنتی http://ijnl.tums.ac.ir/index.php/ijnl/article/viewArticle/293
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