| چکیده انگلیسی مقاله |
Introduction: CVA is one of the most important health problems and it has different irreversible complications. Prevention is of the most important way to deal with this disease. There are several controversies on the effects of homocystein, vitamin B12 and folic acid on this disease. This study as conducted to compare homocystein, vitamin B12 and folic acid levels between those with and without cerebrovascular accident. Materials and Methods: In this case control study, 42 were selected as cases and 20 as controls, using simple non-random sampling. All the information was obtained using their records and their plasma samples. homocystein, vitamin B12 and folic acid level were compared between cases and controls using t-test. Results: Mean vitamin B12 in cases was 388.4±390.3 Pg/ml and in controls was 369.8±110.4 Pg/ml that did not show any significant difference. Mean folic acid in cases was significantly lower than the controls (6.8±4.5 ng/ml vs. 12.2±3.0 ng/ml, P<0.001). Mean homocystein level in cases was significantly higher than the controls (21.1±9.8 µM/L, vs. 13.5±3.2 µM/L, P<0.001). Conclusion: Considering the results of this study and comparing them with the other studies, it seems that mean folic acid and homocystein in those with CVA are lower than the other people. Considering this fact, it is recommended to conduct further prospective studies to evaluate the cause and effect between these supplements and the disease and practical ways of prevention of CVA. Keyword: Cerebrovascular Accident, Folic Acid, Homocystein, Vitamin B12 |
