| چکیده انگلیسی مقاله |
Idiopathic calcification of basal ganglia or Fahr's syndrome is a rare disease characterized by deposition of calcium in cerebral basal ganglia specially globus pallidus. Neurological signs include speech disturbance, gait and movement disorders. Urinary incontinence and seizures have been declared as other complications, too. Mild disturbance of concentration and memory, personality and behavioral changes, psychosis, dementia and mental retardation are categorized as psychiatric manifestations. We report a 56- year old man who had been under the treatment of typical antipsychotic agents for ten years with the diagnosis of psychosis. He withdrew the drugs because of frequent acute dystonias and gradual development of dysarthria. Four years ago he received medication with the diagnosis of hypo-parathyroidism documented on the history of nephrolithiasis and calcification of cerebellar hemispheres on CT Scan. Such treatment-resistant psychotic disorders may lead to considering organic conditions in which prescribing the typical antipsychotics may develop movement disorders and extrapyramidal side effects. Hypoparathyroidism should also be noted as a differential diagnosis. His little sister suffers from mental retardation and choreoathetosis. Also the little brother suffers from the same but milder condition. We will study the whole family to investigate the probable familial pattern of the disease. Keyword: Calcification, Basal Ganglia, Fahr's Syndrome, Psychosis, Mental Retardation, Hypoparathyroidism |
