| چکیده انگلیسی مقاله |
Introduction: To compare between sodium chloride and dextrose 5% solutions in symptoms relief of acute migraine attack. Dehydration has been reported in acute migraine attacks, and fluid replacement therapy could relieve its symptoms. However, administered fluid composition may be effective in headache relief process in acute migraine attacks. Methods: We selected 40 patients with known chronic migraine-type headaches referred to Emergency Department for acute attack of headache, and allocated them in two groups. The first group (N=20, 10 males and 10 females, mean age=29.0 years; SD=5.3 years, mean headache duration=11.4 years; SD=5.0 years) administered with 500 ml of 0.9% sodium chloride solution infusion during 15 minutes. Second group (N=20, 10 males, and 10 females, mean age=27.2 years; SD=7.7 years, mean headache duration=7.2 years; SD=6.1 years) received 500 ml of 5% dextrose solution infusion in 15 minutes. The patients were unaware of administered fluid type and they were monitored for their attacks recur for up to 30 minutes after infusion completed. Results: The reduction in pain severity in all patients in Saline group was considerable and there was no need to use analgesics after about 30 minutes of infusion completion, while dextrose solution group need to take analgesic and anti-emetic therapy after 5 minutes of infusion completed. This was not statistically significant (P=0.143, Fischer’s exact test). On the other hand, nausea and vomiting were the first symptoms relieved during Saline infusion, however, there was no improvement in nausea and vomiting condition in second group. Conclusion: Although not statistically significant, our results could open new horizons in abortive therapy profile of migraine attacks and gleams to make new explanation to headaches pathophysiology. It seems that more clinical studies with greater sample sizes are yet needed in this era. Keyword: Migraine, Abortive Therapy, Normal Saline, Dextrose Water 5% Solution, Nitric Oxide (No) |
