| چکیده انگلیسی مقاله |
Introduction: The purpose of this study is to investigate fatigue in multiple sclerosis (MS), its pathophysiologic factors, the tolerability and the safety of medical and non-medical treatments and methods for measuring fatigue. Methods: Fatigue is common in all types and stages of MS but its pathophysiology is not clear. There are few medications for the treatment of fatigue. Amantadine is the best-known agent although its efficacy and the duration of action are limited. Pemoline and modafinil are also two alternatives affecting fatigue. DAP (diaminopyridine), Aspirin, methylphenidate and fluoxetine are also other medicines in this category that need to be investigated more. Rehabilitation (physiotherapy), regular physical exercises and body cooling are very important in controlling the symptoms of MS. There are different ways for the measurement of fatigue. There is no laboratory marker for fatigue. The result of this short clinical study can be a guide for the diagnosis of MS fatigue, differentiating it from similar physical and mental conditions and the effects of medicines and necessary treatments for MS patients with fatigue. Keyword: Multiple Sclerosis (Ms), Fatigue, Pathophysiology, Treatments, Clinical Aspects, Differential Diagnosis, Measurement |
