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1391/12/10، جلد ۸، شماره ۲، صفحات -
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| عنوان انگلیسی |
Prevention of animal model of multiple sclerosis by oral genistein, extracted from soy bean |
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| چکیده انگلیسی مقاله |
Introduction: Multiple sclerosis (MS) is a chronic and often debilitating demyelinating disease of the central nervous system (CNS). Many of the current treatments are costly, limited in efficacy, and possess unpleasant side effects. These drawbacks bring the protective strategies into the center of attention. Genistein is one of the components of soy bean which happen to have anti-inflammatory, antioxidant and neuroprotective properties. We conducted this study to assess the potential role of genistein in protection against MS. Methods and Materials: We used Experimental Autoimmune Encephalomyelitis (EAE) -an inducible CD4 + T cell-mediated autoimmune disease with pathological features similar to MS. Oral administration of 20 mg/ kg genistein to MOG-immunized mice was started 21 days before the induction of disease and continued for 42 days. Results: It significantly prevented mice from prolonged neurological sequel by postponing the disease onset, attenuating EAE course and alleviating the severity of clinical and histological signs of EAE. Genistein impose its beneficial role by modulating T-helper1/T-helper2 balance by decreasing CD4 + T-helper 1 cells. Furthermore it inhibited encephalogenic and systemic release of IFN-g and IL-12 and encephalogenic secretion of TNF-a. On the contrarily it increase the production of IL-10 in central nervous system and spleen. Conclusion: Taking together, these results suggest that genistein may represent a new protective approach for MS by anti-inflammatory and immune-modulating properties. Keyword: GENISTEIN, EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYLITIS (EAE), ANTI-INFLAMATORY |
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| نویسندگان مقاله |
56147---56148---56149---56150---56151---56152--- |
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| نشانی اینترنتی |
http://ijnl.tums.ac.ir/index.php/ijnl/article/viewArticle/152 |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original Article(s) |
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