| چکیده انگلیسی مقاله |
Introduction: Nowadays, many studies consider a role for magnesium and calcium in pathophysiology and treatment of migraine. We evaluated serum ionized magnesium and calcium level in migraineurs -during interictal period- and control group. Methods: Migraineurs -according to the IHS criteria- enrolled in this study. Serum Mg²+ and Ca²+ level were determined by atomic absorption spectrophotometry. Mean values were compared, using t-test. Results: 40 migraineurs and 40 healthy subjects (34 (85%) female and 6 (15%) male in each group) enrolled the study with mean age of 34.8±9.9 and 35.7±9.1 years, respectively. There were no significant difference between Mg²+ levels in cases vs. healthy subjects (1.55±0.27 vs. 1.55±0.29 meq/l) but serum Ca²+ level was lower in healthy subjects. (8.04±1.18 vs. 7.56±0.82 meq/l, P<0.05). Migraineurs without aura had lower serum Mg²+ level (1.56±0.26 vs. 1.76±0.24 meq/l) and higher serum Ca²+ level (8.10±1.23 vs. 7.64±0.65 meq/l) than with aura migraineurs. Migraineurs with "monthly attack rate ³4" had lower Mg²+ and Ca²+ level (1.48±0.23 vs. 1.58±0.29 meq/l) and (7.95±0.42 vs. 8.09±1.85 meq/l) than those with lower attack rate. Females whose attacks aggravated by menstruation had lower serum Mg²+ and Ca²+ level in comparison with those their attacks didn’t aggravate by menstruation (1.46±0.25 vs. 1.77±0.25 and 7.77±0.59 vs. 8.80±2.77, P<0.05). Conclusion: In our study, severity of migraine had correlation with reduced serum Mg²+ and higher Ca²+ level which confirms the role of reduced magnesium level on lowering the threshold of attacks. Also, lower Mg²+ and higher Ca²+ level in migraineurs without aura could exhibit a demonstrable calcium channelopathy, but also raises questions about possibility of different mechanisms for “with and without aura” migraine. However, it seems that further studies with larger sample size and intra cellular (RBC and monocyte) Mg²+ assessment, is needed. Keyword: Headache, Migraine, Magnesium, Calcium |
