| چکیده انگلیسی مقاله |
Introduction: Thymus gland as a part of immune system can get involved in both malignant and benign conditions. One result of this gland involvement is myasthenia gravis, which causes general weakness of the body especially during activities. In this situation thymus gland produces antibodies that can compete with acetylcholine in neuro muscular junction and inhibits acetylcholine effect on end plate receptors. In this study, we aimed to identify the clinical condition of myasthenic patients before and after thymectomy. Thymus pathology and the recuperation of patients as well as their age, sex and family history were investigated. Methods: 32 thymectomized myasthenic patients in Day hospital (Tehran) were studied. Information such as medical history and signs before and after operation, type of thymus pathology and their improvement after thymectomy were investigated. Results: Form 32 patients, 59.4% were female and 40.6% were male. 84.4% of patients were more them 20 years old. Pathologic results showed that 18.75% of cases were thymoma, 50% thymus hyperplasia and 31.25% were without any pathologic changes. In clinical signs, ptosis was the most frequent complaint, whereas weakness of masticatory muscles had the least frequency. 36.6% of patients had complete improvement, 40% partial improvement and 20% without any changes in the condition of the disease. Furthermore, in only one case the signs of the disease were deteriorated. Keyword: Myasthenia Gravis, Sign, Symptom, Pathology, Thymectomy Conclusion: Although the myasthenia gravis is a rare disease but early diagnosis and performing of thymectomy even before medical treatment can have better therapeutic effects on myasthenic patients. |
