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1393/8/24، جلد ۱، شماره ۱، صفحات -
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
Effect of EPA supplementation on body mass index in overweight hypertriglyceridemic subjects with different FABP2 and PPARα genotypes |
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| چکیده انگلیسی مقاله |
Background: Obesity is a consequence of the excessive accumulation of fat inadipose tissue which can result in significant morbidity and mortality. Obesity is amajor health problem in Iran. The aim of this study was to investigatethe effects of EPA consumption on BMI and fasting blood sugar by FABP2genotypes and PPARα (Leu162Val, and G/C intron polymorphism) genotypes. Methods: A total of 170 hypertriglyceridemic subjects were selected andgenotyped for Ala54Thr, using a polymerase chain reaction–restriction fragmentlength polymorphism (PCR-RFLP) method. After determination of their FABP2genotypes, the first 23 eligible subjects who were determined as Ala54 carriers andthe first 23 eligible Thr54 carriers were enrolled in the study. Participants took 2g/d of pure EPA (four gel caps, each containing 500 mg of ethylester EPA 90%).Height and weight were measured by a Seca scale with light clothing and no shoeson. BMI was then calculated. Waist and hip circumferences were measured with aflexible tape. Results: EPA supplementation decreased fasting blood sugar in Ala54 and Thr54(p<0.001). No significant association was observed between BMI or fasting bloodsugar and different FABP2 genotypes after EPA consumption. EPAsupplementation increased BMI and decreased fasting blood sugar in Lue162 andVal162 (p<0.01), and interon 7 polymorphism (p<0.01). No interaction wasobserved between PPARα genotypes and degree of changes in BMI or fastingblood sugar after EPA supplementation. Conclusion: Although EPA consumption showed the effect of EPA response on FBSin Ala54 or Thr54 and Leu162 or Val162 in FABP2 and PPARα genotypes but nointeraction was observed between these genotypes and EPA supplementation. |
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| کلیدواژههای انگلیسی مقاله |
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| نویسندگان مقاله |
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| نشانی اینترنتی |
http://jnsd.tums.ac.ir/index.php/jnsd/article/viewArticle/46 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original Articles |
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