| چکیده انگلیسی مقاله |
Background: Liver cancer is one of the deadly cancers with high prevalence inthe East Asia. Likewise most of diseases, herbs and herbal medicine could be aneasy and cost effective tool in prevention and possible cancer treatment. Thepresent study investigated the ability of Orthosiphon stamineus Benth decoction toprotect liver against hepatocellular carcinoma in carcinogenesis-induced animalmodel. Methods: Forty male Sprague Dawley rats (age: 8±1 weeks, weight: 248.1±7.21g)were obtained and 10 rats were kept as normal group. Hepatocellular carcinomawas induced for the rest 30 of rats by means of intraperitoneal injection of200mg/kg diethyl nitrosamine (DEN) dissolved in corn oil. Induced cancer ratswere under hepatocarcinogenesis promoter diet made from a mixture of standardrat diet (AIN-76) with 2-acetylaminofluorene (0.02% AAF) for two weeks. Twoweeks after this diet, left over rats were divided to two groups as control andtreatment. Treatment group, were forced feed daily with 0.7 ml O. stamineusdecoction. Results: After 28 weeks treatment with O. stamineus decoction, serumbiochemical markers including alpha fetoprotein (AFP), alkaline phosphatase(ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT),corticosteroid binding globulin (CBG), gamma glutamyl transferase (GGT),homocysteine (HCY), tumor necrosis factor alpha (TNF-α), and alpha 2macroglobulin (α2MG) have been regulated favorably. Total antioxidant status(TAS) also has been increased drastically. Liver lesion score in treated groupswere reduced and glucocorticoid activity has been amplified significantly. Conclusion: Our results indicate that O. stamineus decoction might prevent orsubdue liver cancer development. |
