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1392/9/30، جلد ۲، شماره ۱، صفحات -
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
Relation between the las quorum-sensing system expression and the expression of efflux pump and ampC in clinical isolates of Pseudomonas aeruginosa |
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| چکیده انگلیسی مقاله |
Background: Quorum-sensing systems regulate expression of several virulence factors in Pseudomonas aeruginosa . This study investigated the relation between the las quorum-sensing system expression and expression of mexY and ampC in 35 clinical isolates of P. aeruginosa . Methods: Expression of genes including lasI , lasR , mexY , ampC and ampR was assessed by real time RT–PCR. Results: 28 isolates with elevated expression of mexY and ampC (compared to P. aeruginosa PAO1) were resistance to ceftazidime, imipenem, ciprofloxacin and amikacin. Also these isolates demonstrated increased expression of lasI and lasR . The remaining seven isolates showed intermediate resistance to ciprofloxacin and amikacin. These seven isolates with elevated ampR expression demonstrated decreased expression of mexY , ampC , lasI and lasR . Conclusion: In contrast to previous study, current study demonstrated that the expression pattern of ampC was identical to the lasI expression pattern among clinical isolates. Furthermore according to previous study we expected that AmpR positively regulated ampC expression but in our study, some of the isolates with elevated ampR expression showed decreased ampC expression. The expression pattern of lasR and mexY was identical in all of the isolates. It seems there was a direct or indirect relation between expression of lasR and mexY expression in P. aeruginosa . Keywords: Pseudomonas aeruginosa , Quorum Sensing, efflux pump, β-lactamase. |
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| کلیدواژههای انگلیسی مقاله |
Keywords: Pseudomonas aeruginosa , Quorum Sensing, efflux pump, β-lactamase. |
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| نویسندگان مقاله |
57113---57114---57115--- |
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| نشانی اینترنتی |
http://jmb.tums.ac.ir/index.php/jmb/article/viewArticle/143 |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original Articles |
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