Background & Objectives: Years of life lost (YLL) was designed by the World Health Organization (WHO) to measure and analyze the burden of various diseases. Intentional and unintentional injuries, is the second cause of death in Iran. Since there is little know about the burden of injuries, this study designed to measure YLL in this group as a key indicator of population health and priority setting in health. 
Methods: Years of life lost was calculated based on death data from Death Registration system in Mazandaran province.
Results: During the year 1387 in Mazandaran province, 39,421 years lost due to intentional and unintentional injury. 30,498 years that related to men and 8923 years related to women. In this province injury has been the first cause of YLL in both sexes and age groups 20-24, 25-29 and 15-19 years, respectively.
Conclusion: Considering the results of this study and the high number of years lost due to accidents in the province, especially in men, it seems that more appropriate interventions programs for at risk age group of men in province is required.