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1392/3/5، جلد ۲۳، شماره ۳، صفحات -
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Expression of T-cell Immunoglobulin- and mucin-domain-containing molecule-3 on Lymphocytes from Henoeh-Schonlein Purpura |
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| چکیده انگلیسی مقاله |
Objective: To investigate T-cell immunoglobulin domain and mucin domain-containing molecule-3 (Tim-3) and its ligand galectin-9 mRNA expression in peripheral blood mononuclear cells (PBMCs) from Henoch-Schoenlein Purpura (HSP) patients. Methods: Quantitative real-time reverse transcription-polymerase chain reaction (PCR) was used to examine the mRNA expression of Tim-3 and its ligand galectin-9 in PBMCs from HSP patients. ELISA methods were used to examine the levels of serum IFN-γ and immunoglobulin A1 (IgA1). The Spearman rank test was used for correlation analysis between Tim-3, galectin-9 mRNA expression and serum IFN-γ and IgA1 levels, respectively. Findings : The results showed that Tim-3 and galectin-9 mRNA expression was obviously higher in patients, which was closely correlated with serum IFN-γ and IgA1, respectively. Conclusion: The results suggested that Tim-3/Tim-3L may be related to the pathogenesis of HSP. Key Words: Henoch-Schoenlein Purpura; T-cell Immunoglobulin; Mucin domain containing 3 protein; TIM-3 protein; Immunoglobulin A |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
9405---9406---9407---9408--- |
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| نشانی اینترنتی |
http://ijp.tums.ac.ir/index.php/ijp/article/viewArticle/1414 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Short Communication |
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