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1392/5/9، جلد ۲۳، شماره ۴، صفحات -
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Early Aggressive Parenteral Nutrition Induced High Insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein 3 (IGFBP3) Levels Can Prevent Risk of Retinopathy of Prematurity |
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| چکیده انگلیسی مقاله |
Objective: To evaluate early aggressive vs. conservative nutrition and their effects on ROP in < 32 weeks of gestation neonates. Methods: A prospective, randomized, clinical study was conducted in NICU with a total of 75 preterm infants. In the intervention group, infants were started on early aggressive nutrition immediately after birth, in the control group infants were started on conventional parenteral nutrition. Blood samples were obtained for IGF-I and IGFBP3 levels before commencement of the parental nutrition (PN) on the first postnatal day, and from week 1 to 6 every week. The retinas of all the infants were examined for ROP. Findings : Infants in the early aggressive group had a reduction in the risk of ROP of 5% (2 from 40); the number needed to treat averaged 3.7 (2.7 to 5.2). A total of 11 neonates in the conventional group were detected as having ROP ( P < 0.05). Overall, IGF-I levels were higher in the aggressive PN versus the conventional PN. ROP development was higher in the CPN compared to the APN. IGF-I levels were lower in ROP developers compared with non-ROP in the APN group. There was no difference in IGF-I levels in ROP developers versus non-ROP in the CPN group. IGF-I levels were lower in the CPN group compared with the APN group in the third week in ROP developers. There was a correlation between ROP and IGF-I levels. Through ROC analysis, IGF-I was demonstrated as being a sensitive marker for ROP. Conclusion: IGF-I levels were higher in the aggressive PN group versus the conventional PN group. This may indicate that IGF-I levels simply being higher is not enough; rather, that being higher above a cutoff value may prevent ROP. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
9582---9583---9584---9585---9586---9587--- |
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| نشانی اینترنتی |
http://ijp.tums.ac.ir/index.php/ijp/article/viewArticle/1543 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original Article |
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