1392/11/16، جلد ۲۴، شماره ۱، صفحات -
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عنوان انگلیسی Treatment of Children with Advanced-Stage Lymphoblastic Lymphoma with Pegaspargase
چکیده انگلیسی مقاله Objective: To evaluate the feasibility of Pegaspargase instead of L-asparaginase to treat children with advanced-stage lymphoblastic lymphoma (LBL) on the Berlin-Frankfurt-Munster (BFM)-95 protocol. Methods: Fifty-four newly diagnosed patients with stage III or IV LBL and without any treatment were enrolled in this study. Pegaspargase took place of L-asparaginase in BFM-95. The complications and treatment responses of patients treated on the BFM-95 protocol and modified BFM-95 protocol were then evaluated respectively. Findings : For LBL patients treated with BFM-95 protocol or modified BFM-95 protocol, the complete response, event-free survival, overall survival were similar. Stage 4 myelosuppression was the most common complication in both groups. Besides that, among 31 patients receiving modified BFM-95 protocol, coagulation defects were the most common complication. In contrast, anaphylactic reaction was the most common complication in the other 23 patients receiving BFM-95 protocol. Conclusion: Modified BFM-95 protocol is available to children with advanced-stage LBL with an equal outcome and enhances its compliance and decreases the incidence of anaphylactic reaction, compared to BFM-95 protocol. Coagulation defects are the major complication and tolerable in modified one.
کلیدواژه‌های انگلیسی مقاله Pegaspargase; L-Asparaginase; Lymphoblastic Lymphoma; Chemotherapy
نویسندگان مقاله 10128---10129---10130---10131---10132---
نشانی اینترنتی http://ijp.tums.ac.ir/index.php/ijp/article/viewArticle/2193
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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