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1391/7/21، جلد ۲۲، شماره ۳، صفحات -
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
A Comparison of Buccal Midazolam and Intravenous Diazepam for the Acute Treatment of Seizures in Children |
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| چکیده انگلیسی مقاله |
Objective: The purpose of the present study is to compare efficacy and safety of buccal midazolam with intravenous diazepam in control of seizures in Iranian children. Methods: This is a randomized clinical trial. 92 patients with acute seizures, ranging from 6 months to 14 years were randomly assigned to receive either buccal midazolam (32 cases) or intravenous diazepam (60 cases) at the emergency department of a children's hospital. The primary outcome of this study was cessation of visible seizure activity within 5 minutes from administration of the first dosage. The second dosage was used in case the seizure remained uncontrolled 5 minutes after the first one. Findings : In the midazolam group, 22 (68.8%) patients were relieved from seizures in 10 minutes. Meanwhile, diazepam controlled the episodes of 42 (70%) patients within 10 minutes. The difference was, however, not statistically significant ( P =0.9). The mean time required to control the convulsive episodes after administration of medications was not statistically significant ( P= 0.09). No significant side effects were observed in either group. Nevertheless, the risk of respiratory failure in intravenous diazepam is greater than in buccal midazolam. Conclusion: Buccal midazolam is as effective as and safer than intravenous diazepam in control of seizures. Key Words: Midazolam; Diazepam; Seizure; Buccal Drug Administration; Intravenous Injections; Childhood |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
10915---10916---10917---10918---10919--- |
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| نشانی اینترنتی |
http://ijp.tums.ac.ir/index.php/ijp/article/viewArticle/1623 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original Article |
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