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1391/7/22، جلد ۴، شماره ۱، صفحات -
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
Prevalence of Minor β-thalassemia Based on RBC Indices among Final Suspected Individuals in Premarital Screening Program Referred to Genetic Laboratories |
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| چکیده انگلیسی مقاله |
Abstract Introduction: The current study evaluated the value of red blood cell (RBC) indices and the corresponding cut- off points for β-thalassemia control programs in Iran. Materials and Methods: 1,150 individuals (575 couples) with low RBC indices and normal hemoglobin A2 who had been referred to the Genetic Centre of Isfahan, were tested during pre-marital screening analyses, in the 2 year period, 2006-2008. β-thalassemia mutations were evaluated. Results: β-thalassemia was identified in 67.8% of the cases with both mean corpuscular volume (MCV) less than 78fl and mean corpuscular hemoglobin (MCH) less than 26 pg. However, 4.1% of the individuals with 78≤ MCV≤ 80 tested positive for thalassemia. MCV showed a higher diagnostic reliability than MCH. However, the accompaniment of MCH<26 with MCV<78 increased the risk of thalassemia 35 times. A significant association was found between the prevalence of minor β-thalassemia and educational levels, race and familial relationships. Conclusion: According to the results of this study, it seems that MCV=80fl can be used as a proper cut- off point for the screening of minor β-thalassemia. Although in the present study MCV was found to have a higher diagnostic reliability than MCH, MCH <26 along with MCV are very helpful indices for the counselor physician to estimate the risk of minor β-thalassemia more accurately. Key words: Minor β-Thalassemia, Screening, MCH, MCV, Thalassemia Preventing Program, |
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| کلیدواژههای انگلیسی مقاله |
Minor β-Thalassemia, Screening, MCH, MCV, Thalassemia Preventing Program, |
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| نویسندگان مقاله |
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| نشانی اینترنتی |
http://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/viewArticle/237 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Articles |
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