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1393/7/30، جلد ۴۳، شماره ۱۰، صفحات -
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Effect of Vitamin E and Metformin on Fatty Liver Disease in Obese Children- Randomized Clinical Trial |
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| چکیده انگلیسی مقاله |
Background: We evaluated the effect of vitamin E and metformin on fatty liver disease in obese children. Methods: This interventional study has been done on 119 children with Non-alcoholic fatty liver disease (based on sonography results). Patients were divided into four treatment groups; they received metformin 1gr daily (age< 12 years), metformin 1.5 gr daily (age> 12 years), vitamin E 800 U daily and vitamin E 400 U daily. Liver sonography was performed for patients for two periods of two months. This trial was registered in Iranian Registry of Clinical Trials (IRCT), No.IRCT2013021012421N1 Results: The study group comprised 119 individuals (62 females, 57 males). The mean age was 10± 3.19 yr . There was no significant difference in terms of sex and BMI between the groups. Overall liver sonography showed normal liver in 66 patients (55.46%), 66.63% after two months and 33.37% after four months. After two months, the most therapeutic response observed in the group which received vitamin E 800 u daily (48.1%) and the least therapeutic response was in the group which received vitamin E 400 u daily (14.3%). After four months, the greater response was seen in vitamin E 400 u daily group (45.8%) and the least response in the metformin 1 gram daily group (19%). Conclusion: In comparison with metformin, vitamin E is more influential in remission; however both are efficient in treatment of fatty liver. Vitamin E 400 u daily responses better in four-month treatment. Keywords: Fatty liver disease, Obesity, Children, Metformin, Vitamin E |
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| کلیدواژه‌های انگلیسی مقاله |
Keywords: Fatty liver disease, Obesity, Children, Metformin, Vitamin E |
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| نویسندگان مقاله |
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| نشانی اینترنتی |
http://ijph.tums.ac.ir/index.php/IJPH/article/viewArticle/7196 |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Articles |
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