The aim of this retrospective statistical study was to determine the prevalcence and frequency of age and sex distributions of pemphigus disease. Pemphigus disease classified as autoimmune bullous dermatoses which is a chronic mucocutaneous disease.This study was performed in Razi Hospital and department of oral pathology of dental school, Tehran University of Medical Sciences. The most frequently effected area was buccal moucosa of oral cavity. The most rate of recurrence was found in oral cavity which being more common in middle age females (25-44 years).