Morality and ethics constitute fundamental principles of professional, educational and investigational aspects of medicine and all its branches, including dentistry. There are specific considerations in dental research which could significantly affect the design and progress of scientific projects performed in this field. The aim of the current study was to present an overview of ethical concepts governing dental research and to provide examples of common issues raised during dentistry-related investigations. Establishment of human tooth banks in major research and training centers is suggested to enhance the process of conducting more substantial research in dentistry.