Background and Aim: Nanoleakage can cause discoloration around restoration margins, secondary caries, postoperative sensitivity and finally loss of restoration, thus adequate hybrid layer is of primary importance in prevention of nanoleakage in adhesive restorations. Because of structural differences between primary and permanent dentin, evaluation of nanoleakge in primary teeth is very important. The aim of this study was to evaluate the nanoleakage in composite restorations following application of self -etch and total-etch adhesives in primary and permanent teeth.

Materials and Methods: In this experimental study, Cl V cavities were prepared in buccal surfaces of 20 extracted primary molars and 20 extracted premolars. Each group was divided into 2 subgroups: In group (A), Gluma One Bond and in group (B), iBond adhesive materials were applied. After silver nitrate staining, specimens were mesiodistally sectioned and polished and then SEM examination was carried out to measure the nanoleakage .Data were analyzed statistically using, ANOVA and Duncan tests with p<0.05 as the limit of significance.

Results: Factors tested had no significant effect on each other. Primary teeth showed more nanoleakage than permanent teeth (P<0.05). Mean nanoleakage was significantly higher in cervical than occlusal margins (P<0.05) and also in iBond than in Gluma One Bond in primary teeth (P<0.05). In permanent teeth, the lowest nanoleakage was observed in Gluma One Bond.

Conclusion: The result of this study indicates that the use of total etch dentin adhesives (Gluma One Bond) in bonded restorations results in less nanoleakage in primary and permanent teeth.