1392/8/28، جلد ۴۲، شماره ۱۱، صفحات -
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عنوان انگلیسی Vitamin D Receptor (VDR) Polymorphisms and Late-Onset Alz-heimer’s Disease: An Association Study
چکیده انگلیسی مقاله Background: Late-onset Alzheimer's disease (AD), a genetically heterogeneous neurodegenerative disorder, is the most common form of dementia in people over 65 years old. The role of vitamin D in neuropsychiatric and neurodegenerative disorders such as AD has been supported by epidemiologic investigations and animal models, as well. We examined the association of the vitamin D receptor ( VDR ) gene polymorphisms and late-onset AD in an Iranian population. Methods: This study was performed in Tehran, Iran from 2007 to 2008. Totally, 145 AD patients and 162 age-matched unrelated healthy controls were included. The genotype and allele frequencies for the VDR polymorphisms, ApaI (G>T; rs7975232) and TaqI (C>T; rs731236), were determined in the case and control subjects PCR-RFLP analysis.  Logistic regression analysis was performed to assess the effect of mutant genotype or allele in the study groups. Results: The statistical analyses showed significant differences neither in genotype nor in allele frequencies of the ApaI and TaqI polymorphisms between the case and control groups. Conclusion: It seems that the ApaI and TaqI polymorphisms are not associated with the risk of late-onset AD in Iranian population.   Keywords: Alzheimer’s Disease, Vitamin D Receptor, Polymorphism, Association Study, PCR-RFLP, Iran
کلیدواژه‌های انگلیسی مقاله Keywords: Alzheimer’s Disease, Vitamin D Receptor, Polymorphism, Association Study, PCR-RFLP, Iran
نویسندگان مقاله 2237---2238---2239---2240---2241---2242---
نشانی اینترنتی http://ijph.tums.ac.ir/index.php/IJPH/article/viewArticle/4492
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