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1393/4/7، جلد ۴۳، شماره ۶، صفحات -
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
Analysis of MTHFR Gene C.677C>T and C.1298A>C Polymor-phisms in Iranian Patients with Non-Syndromic Cleft Lip and Palate |
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| چکیده انگلیسی مقاله |
Background: Non-syndromic cleft lip with or without cleft palate (nsCL/P) is one of the most common congenital abnormalities of the orofacial region with a multifactorial etiology. The present study aimed to investigate the association of two common polymorphisms of methylenetetrahydrofolate reductase (MTHFR) gene (c.677C>T and c.1298A>C) with the occurrence of nsCL/P in an Iranian population. Methods : Forty-five nsCL/P patients, 43 mothers of patients, and 101 unrelated controls participated in the present study. Analysis of c.677C>T and c.1298A>C polymorphisms in MTHFR gene was conducted using polymerase chain reaction and restriction enzyme digestions. Results : There was no statistical difference in genotype and allele frequencies for c.677C>T variants between patients or their mothers and the control group. However, differences in the frequencies of alleles and genotypes of c.1298A>C polymorphism were statistically significant between patients and control group ( P =0.01 for alleles and P =0.005 for genotypes). The odds ratios (OR) for the CC versus AA homozygotes were 6.1 (95% CI 1.8-20.5) and 4.2 (95% CI 1.1-15.4), in patients and mothers, respectively. Conclusions : We found no association between genetic polymorphism of MTHFR c.677C>T and the risk of nsCL/P in the population studied. Yet the results suggested that c.1298A>C polymorphism of MTHFR gene may be a risk factor for the occurrence of nsCL/P in the Iranian population. Keywords : MTHFR, Folic acid, Methylenetetrahydrofolate reductase, Cleft Lip, Cleft palate, Non-syndromic cleft |
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| کلیدواژههای انگلیسی مقاله |
Keywords : MTHFR, Folic acid, Methylenetetrahydrofolate reductase, Cleft Lip, Cleft palate, Non-syndromic cleft |
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| نویسندگان مقاله |
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| نشانی اینترنتی |
http://ijph.tums.ac.ir/index.php/IJPH/article/viewArticle/6215 |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Articles |
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