Background: Though many therapeutic modalities have been suggested but still no definite treatment for Cutaneous Leishmaniasis is available. Many compounds including Alkaloid, Quinones, Iridoids, Terpenes, Indole analogue have been documented to have antileishmania activity invitro. On the other hand, the aforementioned compounds can be found in the herbs including Thyme, Yarrow. Propolis is a brown color substance that is collected by honey bee from plants. Regarding the lack of data about the possible efficacy of these herbs against leishmaniasis, we have decided to evaluate and compare the efficacy of herbal extract of Thyme, Yarrow, Propolis and systemic glucantime against cutaneous leishmaniasis in Balb/c, and to formulate drugs without harmful chemical material and without side effect.

Methods: During three weeks of inoculation of parasite in base tail of mice, lesions will appear in the inoculation site. The animals divided into seven groups. We used mix alchoholic extract solution two times a day, checked lesions weekly for six week and measured size of lesion in the base of tail with kulis- vernieh.

Results: We observed significant difference between mean of lesion diameter before and after treatment in control, Yarrow and Thyme groups (p<0.05). Paired t test showed no significant difference between mean of lesion diameter after treatment between treatment and glucantime groups (p>0.05).

Conclusion: Alchoholic extract to Thyme and Yarrow have good effect on lesions treatment, we suggest repeat of this study with Thyme and Yarrow extract in gel or cream base in first stage of lesions appearance.