Background: The results of studies about relationship between depression and positive signs in schizophrenia are controversial and clarifying the nature of this association may be difficult. The aim of present study is to investigate relationship between depressive symptoms and positive signs, in acute phase of patients with chronic schizophrenia, who have been admitted in Roozbeh Hospital.

Materials and Methods: Assessments were performed using the Beck depression Inventory for depression (subjectively) and positive and negative syndrome scale (PANSS) for psychotic symptoms.

Results: The results demonstrated a significant correlation between depressive symptoms and positive signs in these patients. Also, a significant correlation existed between depression and these items: delusions, hallucinatory behavior, excitement, hostility.

Conclusion: depressive symptoms and positive signs in schizophrenia may have a common underlying pathophysiological origin.