By the end of the nineteenth century some countries that had trade relations with Iran established a quarantine stations at the southern ports. This was due to the spreading of cholera and pestilence especially in those regions as well as to a significant number of casualties. Later quarantines were adapted as a tool of colonial influence in order to pressurize the Iranian government.
In fact the quarantine was placed in critical frontiers caused a lot of problem for both the governments and people scattering quarrels in frontier quarantines and excessive letters between Iran and England.
In this review we aimed at surveying documents and papers remained from the past. Also in this review more attention has been paid to some issues which involve reasons of setting up quarantine stations in Iran and the resulted problems for government, frontiersman and pilgrims.