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1392/7/9، جلد ۲۱، شماره ۲، صفحات ۵۳-۵۹
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
Radiosynthesis of 191Os-2-acetylpyridine thiosemicarbazone complex, as an in vivo therapeutic radionuclide generator |
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| چکیده انگلیسی مقاله |
Introduction: Due to the anti-proliferative properties of platinum group-thiosemicarbazone complexes, the production of 191Os-labeled 2-acetyl pyridine 4-N-methylthiosemicarbazone (191Os-APMTS) was investigated. Methods: [191Osmium (T½= 15.4d) was produced via the 190Os(n,γ)191Os nuclear reaction using enriched target irradiated with thermal neutrons. Reaction of in-house synthesized 2-acetylpyridine thiosemicarbazone (APMTS) with 191Os yielded [191Os]APMTS checked by ITLC followed by stability, partition co-efficient and biodistribution determination. Results: Following synthesis and spectroscopic determination of the ligand (>99% chemical purity), the complex was prepared with a radiochemical purity of more than 95% (RTLC) and specific activity of 21.5 GB/mM and was stable in the formulation and presence of human serum at 37°C for up to 48h. The partition coefficient was determined (log P. 1.23). The biodistribution study up to 4 days demonstrated significant tissue uptake differences in the bone, blood, heart and thyroid. Conclusion: This is the first Os-191 labeled thiosemicarbazone designed as an in-vivo therapeutic radionuclide generator. Further investigation is ongoing on the evaluation of the complex in tumor bearing animals. |
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| کلیدواژههای انگلیسی مقاله |
Iran, meta-analysis, trend of infertilityGated myocardial perfusion SPECT, Quantification, segmental scoring, Meckel’s scan, Meckel’s diverticulum, Gastrointestinal bleeding, Technetium Pertechnetate scintigraphy, Thiosemicarbazone, 191Os, Radiolabeling, Biodistribution, |
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| نویسندگان مقاله |
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| نشانی اینترنتی |
http://irjnm.tums.ac.ir/pdf_3242_b3e0e8b548ef45b4ea4fd3cc9a7b2517.html |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
eng |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original Articles |
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