1393/9/23، جلد ۲۳، شماره ۱، صفحات ۱۵-۲۰

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چکیده فارسی مقاله
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عنوان انگلیسی Development of a freeze-dried radiopharmaceutical kit for dopamine transporters imaging
چکیده انگلیسی مقاله Introduction: 99mTc-TRODAT-1 is a promising new radiopharmaceutical with the potential for routine use as the radiopharmaceutical for dopamine transporters scintigraphy as far as its image quality and daily availability are concerned. Here we describe the development of a freeze-dried kit formulation based on the tricine exchange labeling approach for the preparation of this radiopharmaceutical in a clinical setting. Methods: A freeze-dried formulation contained of TRODAT-1, tricine, SnCl2 and manitol was prepared. Labeling was performed by addition of 1480 MBq 99mTc sodium pertechnetate in a total volume of 2 mL and incubation for 15 min in a boiling water bath. Radiochemical analysis involved ITLC and HPLC methods. The stability of radioconjugate was checked in the presence of human serum at 37 °C up to 24 h. Results: 99mTc-TRODAT-1 was prepared with a radiochemical purity of >95% and a high stability up to 24 h of the final preparation, and retained biological activity. Conclusion: The developed kit formulation forms the basis for further clinical evaluation of this promising new radiopharmaceutical.
کلیدواژه‌های انگلیسی مقاله Iran, meta-analysis, trend of infertilityGated myocardial perfusion SPECT, Quantification, segmental scoring, Meckel’s scan, Meckel’s diverticulum, Gastrointestinal bleeding, Technetium Pertechnetate scintigraphy, Thiosemicarbazone, 191Os, Radiolabeling, Biodistribution, RBBB, Myocardial perfusion, Gated SPECT, Coronary artery disease, Effective dose, Nuclear medicine procedures, Collective effective dose, Tc99m MIBI parathyroid scintigraphy, Myocardium perfusion gated SPECT, Parathyroid adenoma, Skeletal scintigraphy, Fluid restriction, Tc-99m MDP, Image quality, Bone to soft tissue ratio, Radiology, Nuclear medicine, Medical imaging, Bibliometric study, Iran, Hyperthyroidism, Radioactive iodine, Sexual hormones, Semen analysis, Attenuation correction, Artifact, Color intensity, SPECT, Thyroid, I-131, Absorbed ratio, Monte-Carlo, Absorbed dose, MCNP-4A, Carcinoid Tumor, Liver metastases, ¹³¹I-MIBG scintigraphy, Quality Control, PET, 82mRb, 82Kr, Myocardial perfusion, Drug delivery systems, Gamma-scintigraphy, Neutron activation, Pharmacoscintigraphy, Post stroke dementia, Cerebral perfusion SPECT, ECD, 99mTc-DTPA, Renography, Deconvolution, Renal transit time parameters, Nuclear medicine, PET tracer, Gallium, Copper, Tc-94m, Minimally invasive radio-guided surgery, Hyperparathyroidism, Tc-99m sestamibi, Parathyroid adenoma, Parathyroid hyperplasia, Bombesin, 99mTc, Tumor, HYNIC, Radioiodine therapy, TLD, Thyroid cancer, Absorbed dose, Myocardial perfusion scan, Ischemic heart disease, Risk factors, Demographic data, Military hospital, Evidence based medicine, Nuclear medicine, Evidence based medicine, Nuclear medicine, Critical appraisal, Sensitivity, Specificity, Cavernous hemangioma, Radionuclide imaging, 99mTc-RBC, Attenuation correction, Myocardial perfusion, SPECT, Radio-iodine therapy, Liothyronine, Thermoluminescent dosimeter, Accumulated dose, Exposure rate, 106Ru eye plaque, Dose calculation, Mathematical human eye model, MCNP4C code, Sentinel lymph node, Tc-99m antimony sulfide colloid, Lymphoscintigraphy, Skin marking, Osteoporosis, Type 2 diabetes, Postmenopausal, BMD, Streptokinase, Gallium-67, Thrombosis, SPECT, Radiopharmaceuticals, Breast uptake, Myocardial perfusion scan, Tc-99m sestamibi, Tc-99m pertechnetate scan, Meckel’s diverticulum, Gastrointestinal bleeding, PET, Sensitivity, SPECT, Spatial resolution, Temporal resolution, Dynamic imaging, Attenuation, Collimator, Random coincidence, Animal imaging, Dual isotope imaging, Time-of-Flight, Artifact, Bone scan, Catheter, PSA, Prostate, RIA, Standard matrix, Human serum, Myocardial perfusion scan, Leptin, BMI, [14C]Clozapine, Radiochemical purity, High performance liquid chromatography, Liquid scintillation spectrometer, Renography, Diuretic, 99mTc-DMSA, Differential renal function, Complications, Dipyridamole, Blood pressure changes, 99mTc-MIBI, Brain SPECT, Brain tumor recurrence, Radiation necrosis, Neuroendocrine tumors, Somatostatin receptors, Targeted therapy, Sm-153, EDTMP, Radiopharmaceutical, Therapy, Biological evaluation, Ursodeoxycholic acid, Hepatobiliary scintigraphy, 99mTc-BRIDA, Infantile jaundice, Neonatal hyperbilirubinemia, Positron emission tomography (PET), Scanner performance, Gate, Gallium-67 scintigraphy, Infection animal models, SPECT, Staphylococcus aureus, Escherichia coli, Candidae albicans, PET/CT, Dual energy CT, Attenuation correction, Von Hippel Lindau syndrome, Medullary carcinoma, PET/CT, Bone mlnearl density, Gruen zones, Orthoped software, Dual energy x-ray absorptiometry, Total hip arthroplasty, Clinical, PET/CT, fdg, Anatometabolic imaging, Oncology, Brain imaging, Cardiology, 2D vs. 3D, BGO, LSO, LYSO, GSO, Metastases, Medullary thyroid carcinoma, 99mTc-DMSA (V), Depression, Myocardial perfusion, Scintigraphy, SPECT, Liver hemangioma, Planar scan, Space occupying lesion, 99mTc-RBC, Attenuation correction, Myocardial perfusion, SPET, Emission scanning, Transmission scanning, Hybridoma, Radioimmunoassay technique, Protein G, Tyr3-Octreotide, Quality Control, Radiochemical purity, 99mTc ، Tyr3-Octreotate, PET imaging, Radiochemical, Fluorine-18, Myocardium, Scopus, Citation tracking, Google scholar, SCImago journal rank indicator, Iranian Journal of Nuclear Medicine, Indium-111, maltolate, Cell labeling, Biodistribution, Osteoporosis, discordance, densitometry, Menopause, Kidney transplantation, Myocardial perfusion, Myocardial function, Gated-SPECT, Tc-99m Phytate, Lymphoscintigraphy, Breast cancer, Sentinel node, Detection rate, FDG uptake in skeletal muscle, FDG PET/CT, FDG uptake phase, Exercise induced FDG uptake, Herniation, Urinary baladder, Bone scan, MDP, Diaphragmatic hernia, Intrathoracic kidney, Bowel in thorax, DTPA renogram, Tc-99m EC, Transplanted kidney, Vesicoureteral reflux, Renal scintigraphy, Salivary gland, Radioactive iodine, Xerostomia, Impact factor, Google scholar, h5-index, h5-median, SCImago journal rank indicator, Radiopharmaceutical, Trodat-1, Kit, Dopamine transporters,

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