1389/10/6، جلد ۱۸، شماره ۲، صفحات ۱-۸

عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی Production and quality control of 166Ho-Chitosan for therapeutic applications
چکیده انگلیسی مقاله Introduction: In this research, [166Ho]Holmium chitosan complex production is described in details, followed by determination of complex radiochemical purity, stability and biodistribution (after intra-articular injection) in wild-type male rats. Finally a Ho-166 based chitosan kit for ultimate radiosynovectomy as well as radiotherapy applications was developed.Methods: 166Ho-chitosan complex was prepared using chitosan concentrations and 166HoCl3 followed by intra-articular injection and biodistribution studies in wild-type rats including and excluding injected knee.Results: The [166Ho]Holmium chitosan complex was prepared with high radiochemical yield (>95 %) in the optimized condition (35mg/3ml of chitosan  in %1 AcOH, pH. 3, >98%, ITLC) was injected to wild-type rats followed by the biodistribution studies of the compound among the tissues excluding the injected knee data. Intra-articular injection of [166Ho]holmium chitosan complex to male wild-type rats and investigation of leakage of activity in  the body showed that most of injected dose has remained in injection site 144 h after injection. Conclusion: Successful development and formulation of 166Ho-chitosan kit is described. This kit has the potential for use in clinical setting namely for radiosynovectomy and cancer radiochemotherapy.
کلیدواژه‌های انگلیسی مقاله Iran, meta-analysis, trend of infertilityGated myocardial perfusion SPECT, Quantification, segmental scoring, Meckel’s scan, Meckel’s diverticulum, Gastrointestinal bleeding, Technetium Pertechnetate scintigraphy, Thiosemicarbazone, 191Os, Radiolabeling, Biodistribution, RBBB, Myocardial perfusion, Gated SPECT, Coronary artery disease, Effective dose, Nuclear medicine procedures, Collective effective dose, Tc99m MIBI parathyroid scintigraphy, Myocardium perfusion gated SPECT, Parathyroid adenoma, Skeletal scintigraphy, Fluid restriction, Tc-99m MDP, Image quality, Bone to soft tissue ratio, Radiology, Nuclear medicine, Medical imaging, Bibliometric study, Iran, Hyperthyroidism, Radioactive iodine, Sexual hormones, Semen analysis, Attenuation correction, Artifact, Color intensity, SPECT, Thyroid, I-131, Absorbed ratio, Monte-Carlo, Absorbed dose, MCNP-4A, Carcinoid Tumor, Liver metastases, ¹³¹I-MIBG scintigraphy, Quality Control, PET, 82mRb, 82Kr, Myocardial perfusion, Drug delivery systems, Gamma-scintigraphy, Neutron activation, Pharmacoscintigraphy, Post stroke dementia, Cerebral perfusion SPECT, ECD, 99mTc-DTPA, Renography, Deconvolution, Renal transit time parameters, Nuclear medicine, PET tracer, Gallium, Copper, Tc-94m, Minimally invasive radio-guided surgery, Hyperparathyroidism, Tc-99m sestamibi, Parathyroid adenoma, Parathyroid hyperplasia, Bombesin, 99mTc, Tumor, HYNIC, Radioiodine therapy, TLD, Thyroid cancer, Absorbed dose, Myocardial perfusion scan, Ischemic heart disease, Risk factors, Demographic data, Military hospital, Evidence based medicine, Nuclear medicine, Evidence based medicine, Nuclear medicine, Critical appraisal, Sensitivity, Specificity, Cavernous hemangioma, Radionuclide imaging, 99mTc-RBC, Attenuation correction, Myocardial perfusion, SPECT, Radio-iodine therapy, Liothyronine, Thermoluminescent dosimeter, Accumulated dose, Exposure rate, 106Ru eye plaque, Dose calculation, Mathematical human eye model, MCNP4C code, Sentinel lymph node, Tc-99m antimony sulfide colloid, Lymphoscintigraphy, Skin marking, Osteoporosis, Type 2 diabetes, Postmenopausal, BMD, Streptokinase, Gallium-67, Thrombosis, SPECT, Radiopharmaceuticals, Breast uptake, Myocardial perfusion scan, Tc-99m sestamibi, Tc-99m pertechnetate scan, Meckel’s diverticulum, Gastrointestinal bleeding, PET, Sensitivity, SPECT, Spatial resolution, Temporal resolution, Dynamic imaging, Attenuation, Collimator, Random coincidence, Animal imaging, Dual isotope imaging, Time-of-Flight, Artifact, Bone scan, Catheter, PSA, Prostate, RIA, Standard matrix, Human serum, Myocardial perfusion scan, Leptin, BMI, [14C]Clozapine, Radiochemical purity, High performance liquid chromatography, Liquid scintillation spectrometer, Renography, Diuretic, 99mTc-DMSA, Differential renal function, Complications, Dipyridamole, Blood pressure changes, 99mTc-MIBI, Brain SPECT, Brain tumor recurrence, Radiation necrosis, Neuroendocrine tumors, Somatostatin receptors, Targeted therapy, Sm-153, EDTMP, Radiopharmaceutical, Therapy, Biological evaluation, Ursodeoxycholic acid, Hepatobiliary scintigraphy, 99mTc-BRIDA, Infantile jaundice, Neonatal hyperbilirubinemia, Positron emission tomography (PET), Scanner performance, Gate, Gallium-67 scintigraphy, Infection animal models, SPECT, Staphylococcus aureus, Escherichia coli, Candidae albicans, PET/CT, Dual energy CT, Attenuation correction, Von Hippel Lindau syndrome, Medullary carcinoma, PET/CT, Bone mlnearl density, Gruen zones, Orthoped software, Dual energy x-ray absorptiometry, Total hip arthroplasty, Clinical, PET/CT, fdg, Anatometabolic imaging, Oncology, Brain imaging, Cardiology, 2D vs. 3D, BGO, LSO, LYSO, GSO, Metastases, Medullary thyroid carcinoma, 99mTc-DMSA (V), Depression, Myocardial perfusion, Scintigraphy, SPECT, Liver hemangioma, Planar scan, Space occupying lesion, 99mTc-RBC, Attenuation correction, Myocardial perfusion, SPET, Emission scanning, Transmission scanning, Hybridoma, Radioimmunoassay technique, Protein G, Tyr3-Octreotide, Quality Control, Radiochemical purity, 99mTc ، Tyr3-Octreotate, PET imaging, Radiochemical, Fluorine-18, Myocardium, Scopus, Citation tracking, Google scholar, SCImago journal rank indicator, Iranian Journal of Nuclear Medicine, Indium-111, maltolate, Cell labeling, Biodistribution, Osteoporosis, discordance, densitometry, Menopause, Kidney transplantation, Myocardial perfusion, Myocardial function, Gated-SPECT, Tc-99m Phytate, Lymphoscintigraphy, Breast cancer, Sentinel node, Detection rate, FDG uptake in skeletal muscle, FDG PET/CT, FDG uptake phase, Exercise induced FDG uptake, Herniation, Urinary baladder, Bone scan, MDP, Diaphragmatic hernia, Intrathoracic kidney, Bowel in thorax, DTPA renogram, Tc-99m EC, Transplanted kidney, Vesicoureteral reflux, Renal scintigraphy, Salivary gland, Radioactive iodine, Xerostomia, Impact factor, Google scholar, h5-index, h5-median, SCImago journal rank indicator, Radiopharmaceutical, Trodat-1, Kit, Dopamine transporters, Thyroid cancer, complaints, quality of life, clinical symptoms, complication, Asymptomatic ischemia, Diabetes mellitus, Myocardial perfusion scintigraphy, Gated SPECT, AMD3100, Targeted radiotherapy, Radiolabeling, Biodistribution, Sm-153, 188Re-HEDP, Bone pain, Palliation therapy, Metastasis, Myocardial perfusion SPECT, Perfusion quantification, Polar map, Scoring system, MDP bone scan, FDG PET, Osteomyelitis, Necrotizing fasciitis, Acute myeloid leukemia, Avascular osteonecrosis, Multifocal, Alcohol, Bone scan, Polyarthritis, 99mTc-MIBI scientimammography, Breast cancer, Medical image analysis, Surface fitting, Contour detection, Curvature, Urinary tract infection, Vesico-ureteral reflux, Radioisotopic scan, Tc-99m DMSA, Renal scar, Acute myocardial infarction, Coronary Angiography, Coronary artery disease, SPECT, Head and neck irradiation, Thyroid cancer, Thyroid ultrasonography, Thyroid scan, Monoclonal antibody (MAB), Diethylentriaminepantaaceticacide (DTPA), Indium-111 (¹¹¹In), Fast performance liquid chromatography (FPLC), Chitosan, Holmium-166, Hepatic cancer, Radiosynovectomy, Biodistribution,

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