1390/9/21، جلد ۱۹، شماره ۲، صفحات ۵۲-۵۹

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عنوان انگلیسی Assessment of the impact of applying attenuation correction on the accuracy of activity recovery in Tc99m-ECD brain SPECT of healthy subject using Statistical Parametric Mapping (SPM)
چکیده انگلیسی مقاله Introduction: Photon attenuation in tissues is the primary physical degrading factor limiting both visual qualitative interpretation and quantitative analysis capabilities of reconstructed Single Photon Emission Computed Tomography (SPECT) images. The aim of present study was to investigate the effect of attenuation correction on the detection of activation foci following statistical analysis with SPM. Methods: The study population consisted of twenty normal subjects (11 male, 9 female, and age 30-40 years). SPECT images were reconstructed using filter back projection and attenuation correction was done by the Chang method. The SPECT imagings was obtained 20 min after intravenous injection of 740-1110 MBq (20-30 mCi) of Tc99m-ECD and were acquired on 128×128 matrices with a 20% symmetric energy window at 140 keV. These data publicly distributed by the Society of Nuclear Medicine of Toronto Hospital. The data was standardized with respect to the Montreal Neurological Institute (MNI) atlas with a 12 parameter affine transformations. Images were then smoothed by a Gaussian filter of 10 mm FWHM. Significance differences between SPECT images were estimated at every voxel using statistical t-test and p-value as the significant criteria was set at 0.05. Results: The contrast comparing non attenuation corrected to attenuation corrected images suggest that regional brain perfusion activity increase in the cerebrum, frontal (T-value 12.06) , temporal (T-value 10.63) and occipital (T-value 9.31) lobe and decrease in the sub-lobar, extra-nuclear (T-value 17.46) and limbic lobe, posterior cingulate (T-value 17.46) before attenuation correction compare with attenuation correction. Conclusion: It can be concluded that applying attenuation correction in brain SPECT can effectively improve the accuracy of the detection of activation area (p
کلیدواژه‌های انگلیسی مقاله Iran, meta-analysis, trend of infertilityGated myocardial perfusion SPECT, Quantification, segmental scoring, Meckel’s scan, Meckel’s diverticulum, Gastrointestinal bleeding, Technetium Pertechnetate scintigraphy, Thiosemicarbazone, 191Os, Radiolabeling, Biodistribution, RBBB, Myocardial perfusion, Gated SPECT, Coronary artery disease, Effective dose, Nuclear medicine procedures, Collective effective dose, Tc99m MIBI parathyroid scintigraphy, Myocardium perfusion gated SPECT, Parathyroid adenoma, Skeletal scintigraphy, Fluid restriction, Tc-99m MDP, Image quality, Bone to soft tissue ratio, Radiology, Nuclear medicine, Medical imaging, Bibliometric study, Iran, Hyperthyroidism, Radioactive iodine, Sexual hormones, Semen analysis, Attenuation correction, Artifact, Color intensity, SPECT, Thyroid, I-131, Absorbed ratio, Monte-Carlo, Absorbed dose, MCNP-4A, Carcinoid Tumor, Liver metastases, ¹³¹I-MIBG scintigraphy, Quality Control, PET, 82mRb, 82Kr, Myocardial 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code, Sentinel lymph node, Tc-99m antimony sulfide colloid, Lymphoscintigraphy, Skin marking, Osteoporosis, Type 2 diabetes, Postmenopausal, BMD, Streptokinase, Gallium-67, Thrombosis, SPECT, Radiopharmaceuticals, Breast uptake, Myocardial perfusion scan, Tc-99m sestamibi, Tc-99m pertechnetate scan, Meckel’s diverticulum, Gastrointestinal bleeding, PET, Sensitivity, SPECT, Spatial resolution, Temporal resolution, Dynamic imaging, Attenuation, Collimator, Random coincidence, Animal imaging, Dual isotope imaging, Time-of-Flight, Artifact, Bone scan, Catheter, PSA, Prostate, RIA, Standard matrix, Human serum, Myocardial perfusion scan, Leptin, BMI, [14C]Clozapine, Radiochemical purity, High performance liquid chromatography, Liquid scintillation spectrometer, Renography, Diuretic, 99mTc-DMSA, Differential renal function, Complications, Dipyridamole, Blood pressure changes, 99mTc-MIBI, Brain SPECT, Brain tumor recurrence, Radiation necrosis, Neuroendocrine tumors, Somatostatin receptors, 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Radioimmunoassay technique, Protein G, Tyr3-Octreotide, Quality Control, Radiochemical purity, 99mTc ، Tyr3-Octreotate, PET imaging, Radiochemical, Fluorine-18, Myocardium, Scopus, Citation tracking, Google scholar, SCImago journal rank indicator, Iranian Journal of Nuclear Medicine, Indium-111, maltolate, Cell labeling, Biodistribution, Osteoporosis, discordance, densitometry, Menopause, Kidney transplantation, Myocardial perfusion, Myocardial function, Gated-SPECT, Tc-99m Phytate, Lymphoscintigraphy, Breast cancer, Sentinel node, Detection rate, FDG uptake in skeletal muscle, FDG PET/CT, FDG uptake phase, Exercise induced FDG uptake, Herniation, Urinary baladder, Bone scan, MDP, Diaphragmatic hernia, Intrathoracic kidney, Bowel in thorax, DTPA renogram, Tc-99m EC, Transplanted kidney, Vesicoureteral reflux, Renal scintigraphy, Salivary gland, Radioactive iodine, Xerostomia, Impact factor, Google scholar, h5-index, h5-median, SCImago journal rank indicator, Radiopharmaceutical, Trodat-1, Kit, Dopamine transporters, Thyroid cancer, complaints, quality of life, clinical symptoms, complication, Asymptomatic ischemia, Diabetes mellitus, Myocardial perfusion scintigraphy, Gated SPECT, AMD3100, Targeted radiotherapy, Radiolabeling, Biodistribution, Sm-153, 188Re-HEDP, Bone pain, Palliation therapy, Metastasis, Myocardial perfusion SPECT, Perfusion quantification, Polar map, Scoring system, MDP bone scan, FDG PET, Osteomyelitis, Necrotizing fasciitis, Acute myeloid leukemia, Avascular osteonecrosis, Multifocal, Alcohol, Bone scan, Polyarthritis, 99mTc-MIBI scientimammography, Breast cancer, Medical image analysis, Surface fitting, Contour detection, Curvature, Urinary tract infection, Vesico-ureteral reflux, Radioisotopic scan, Tc-99m DMSA, Renal scar, Acute myocardial infarction, Coronary Angiography, Coronary artery disease, SPECT, Head and neck irradiation, Thyroid cancer, Thyroid ultrasonography, Thyroid scan, Monoclonal antibody (MAB), Diethylentriaminepantaaceticacide (DTPA), Indium-111 (¹¹¹In), Fast performance liquid chromatography (FPLC), Chitosan, Holmium-166, Hepatic cancer, Radiosynovectomy, Biodistribution, Bombesin, HYNIC, Freeze-dried Kit, GRP receptors, Tumor, 99mTc-UBI 29–41, Ubiquicidin, Diabetic foot, Infection, Radiolabeled peptide, Radiolabeling, Quality Control, [64Cu]ATSM, Rabbits, Biodistribution, Coincidence imaging, Evidence based medicine, Journal club, Nuclear medicine, Critical appraisal, 99mTc- ciprofloxacin, Infection imaging, Kit preparation, Cuboid fracture, Bone Scintigraphy, Limping, Toddler fracture, Bone scan, Visualization of colon, Soft tissue uptake, Tc-99m MDP, Radioiodine, Hyperthyroidism, Toxic goiter, Toxic nodule, I-131, 67Gallium, SPECT, Planar imaging, Lymphoma, Time of imaging, 8-Hydroxy-2-methylquinoline, In-111, Biodistribution, SPECT, Hyperthyroidism, Hypothyroidism, Differentiated thyroid carcinoma, Echocardiography, Tissue doppler imaging, Calcitonin, Radiolabeling, Biodistribution, Ga-67, Coronary artery disease, Myocardial perfusion imaging, Coronary artery calcification score, SPM, SPECT, Attenuation correction, Activation foci,

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