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1393/9/2، جلد ۸، شماره ۴، صفحات -
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
Association between Angiotensinogen M235T Polymorphism and Preeclampsia in Iranian Pregnant Women |
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| چکیده انگلیسی مقاله |
Objective: To determine the possible association between the M235T variant of angiotensinogen gene and preeclampsia in Iranian preeclamtic women with hypertension during pregnancy. Materials and methods: During a case control study, we used polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP) analysis to investigate the association between M235T polymorphism in preeclamtic women compared to normotensive controls. Results: The M235T polymorphism was significantly associated with increasedpreeclampsia risk in the studied population as supported by a p value of 0.017 and chi-square value of 8.12. The frequency of mutated allele and genotype distribution showed a significant difference between preeclamtic women and control groups. Conclusion: The result indicates that the AGT M235T polymorphism playsa significant role in preeclampsia observed in selected Iranian preeclamtic women, and it can be considered as a major risk factor for preeclampsia. |
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| کلیدواژههای انگلیسی مقاله |
Angiotensinogen M235T Polymorphism, Preeclampsia |
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| نویسندگان مقاله |
32218---32219---32220---32221---32222---32223--- |
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| نشانی اینترنتی |
http://jfrh.tums.ac.ir/index.php/jfrh/article/viewArticle/445 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
ORIGINAL ARTICLES |
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