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1391/7/28، جلد ۴، شماره ۴، صفحات -
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
Effect of Metformin on Diabetes Mellitus Prevention in Pregnant Women with Risk Factors |
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| چکیده انگلیسی مقاله |
Objective: This study evaluated the efficacy and safety of metformin on prevention of gestational diabetes mellitus in women with high risk of GDM. Materials and methods: Total number of 189 pregnant women aged between 25 to 35, and 10 to 14 weeks pregnancy,admitted to Mirza Koochakkhan Hospital, Tehran in January 2008 - January 2009 entered to this randomized controlled clinical trial. The women had one of the three risk factors; history of GDM, family history of diabetes, or BMI ≥ 30 kg/m 2 , with normal results in the glucose challenge test (GCT) or the glucose tolerance test (GTT). Subjects were randomly split to two groups; 63 women (group A) who received metformin (500 mg, twice a day) and 126 women (group B) did not use metformin. Incidence of gestational diabetes was compared between two groups. Results: The incidence of gestational diabetes was significantly different between two groups (%1.4 in group A, %15.4 in group B) ( p <0.001). The study also showed that the insulin requirement was significantly different between two groups after developing GDM (group A %3.6, group B %9.5, p =0.001). Conclusion: Using Metformin can effectively reduce the incidence of GDM in pregnant women at risk. |
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| کلیدواژههای انگلیسی مقاله |
Gestational diabetes mellitus, Metformin, Prevention, |
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| نویسندگان مقاله |
32337---32338---32339---32340---32341--- |
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| نشانی اینترنتی |
http://jfrh.tums.ac.ir/index.php/jfrh/article/viewArticle/266 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
ORIGINAL ARTICLES |
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