Volume 81, Issue 11 (February 2024)
Tehran Univ Med J 2024, 81(11): 836-845 |
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heydari S, Nasrollahi M, Khodashenas roudsari M. Prevalence of acute kidney injury and its correlation with disease severity and outcomes in COVID-19 patients. Tehran Univ Med J 2024; 81 (11) :836-845
URL: http://tumj.tums.ac.ir/article-1-12885-en.html
URL: http://tumj.tums.ac.ir/article-1-12885-en.html
1- Department of Internal Medicine, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran.
2- Department of Internal Medicine, Shaheed Rajaee Hospital, Ramsar International Campus, Mazandaran University of Medical Sciences, Ramsar, Iran.
2- Department of Internal Medicine, Shaheed Rajaee Hospital, Ramsar International Campus, Mazandaran University of Medical Sciences, Ramsar, Iran.
Abstract: (239 Views)
Background: Studies of viral pandemics in the past, as well as studies of patients with sepsis, have shown that there is a direct relationship between the occurrence of AKI with disease severity and mortality, prognosis and outcomes. Considering that the COVID-19 disease is a novel pandemic and there is not enough information on the occurrence of AKI with COVID outcomes and its consequences, especially in Iran, it is necessary to conduct research in this field.
Methods: This is a retrospective study on 310 Covid patients hospitalized in the internal medicine, critical care and infectious disease ward of Birjand Valiasr Hospital from 20 March 2020 until 20 March 2021. Data were collected from the hospital's health information unit. The information was collected including demographics, underlying diseases, vital signs, laboratory information, and imaging and type of respiratory support. Finally, data was analyzed by SPSS V.22.
Methods: This is a retrospective study on 310 Covid patients hospitalized in the internal medicine, critical care and infectious disease ward of Birjand Valiasr Hospital from 20 March 2020 until 20 March 2021. Data were collected from the hospital's health information unit. The information was collected including demographics, underlying diseases, vital signs, laboratory information, and imaging and type of respiratory support. Finally, data was analyzed by SPSS V.22.
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Results: 310 patients with an average age of 51.9 ± 17.4 participated in this study, 58.4% of them were male. The prevalence of acute kidney injury in patients was 7.4%. There was a significant relationship between acute kidney injury and the COVID severity, so that the COVID severity increases with the occurrence of acute kidney injury. There was a significant relationship between COVID outcomes and acute kidney injury, so that a higher mortality rate was observed in patients with acute kidney injury. No significant relationship was found between the occurrence of acute kidney injury and the score of pulmonary involvement. Patients with hypertension were more tent to experience acute kidney injury. Also, patients with acute kidney injury have more leukocytosis compared to patients without acute kidney injury. In this study, no significant relationship was observed between lymphocyte count and acute kidney injury. This study showed that the level of serum CRP and BUN are significantly higher in patients with acute kidney injury.
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Conclusion: Acute kidney injury in hospitalized patients with COVID-19 is not common but had a significant effect on disease severity and outcomes.
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Type of Study: Original Article |
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