Volume 81, Issue 11 (February 2024)
Tehran Univ Med J 2024, 81(11): 846-858 |
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Dehghan A, Abshirini M, Nemati H, Saeedi-Moghadam M. Evaluating the role of brain MRI in predicting clinical outcome of global developmental delay in children. Tehran Univ Med J 2024; 81 (11) :846-858
URL: http://tumj.tums.ac.ir/article-1-12886-en.html
URL: http://tumj.tums.ac.ir/article-1-12886-en.html
1- Department of Radiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.| Medical Imaging Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
2- Department of Radiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
3- Shiraz Neuroscience Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
4- Medical Imaging Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
2- Department of Radiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
3- Shiraz Neuroscience Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
4- Medical Imaging Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Abstract: (86 Views)
Background: Developmental disorders in children include a group of problems and limitations in learning and acquiring specific skills of each age group. The term global developmental delay is used to describe developmental disability in children under five years of age, which is in at least two areas of major development. Neuroradiological imaging such as brain MRI provides important information for physicians. The purpose of this study is to determine the role of brain MRI in predicting the clinical outcome of global developmental delay in children.
Methods: In this cross-sectional study, from 79 - from September 2013 to September 2018 at Motahari Clinic of Shiraz University of Medical Sciences, Shiraz Iran - eligible children with developmental disabilities, 37 patient who had brain MRI were selected as a sample and children scores in five ASQ clinical areas and MRI findings were reviewed and compared. Patients suffering from metabolic, genetic, trauma, infection and neoplasms problems and diseases were excluded from the study.
Methods: In this cross-sectional study, from 79 - from September 2013 to September 2018 at Motahari Clinic of Shiraz University of Medical Sciences, Shiraz Iran - eligible children with developmental disabilities, 37 patient who had brain MRI were selected as a sample and children scores in five ASQ clinical areas and MRI findings were reviewed and compared. Patients suffering from metabolic, genetic, trauma, infection and neoplasms problems and diseases were excluded from the study.
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Results: Out of 37 patients studied, 23 were female and 14 were male with a dispersion of three 3 to 60 months of age. 31 of these children had at least one abnormal finding in brain MRI images and the other six were completely normal. In relation to the imaging findings, the highest frequency is related to abnormal head circumference with a prevalence of 54% and the lowest frequency is related to abnormal myelinization with a prevalence of 10.8%. Results of MRI findings correlation with developmental domains demonstrated that Children with white matter disorder on MRI show severe gross motor abnormality (P<0.049) and who had MRI finding of cortical problems suffer from developmental delay in fine motor area. (P<0.001).
Conclusion: Considering the mentioned findings; brain MRI can be a useful diagnostic tool in children with developmental delay and also focusing on the developmental area that is more likely to be affected, MRI can help with treatment and rehabilitation process of these children in the future. |
Type of Study: Original Article |
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