Volume 82, Issue 4 (July 2024)
Tehran Univ Med J 2024, 82(4): 314-322 |
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Kalani N, Zabetian H, Shafa S, Alirezai E, Eftekharian F, Sahraei R. The effect of adding two doses of epinephrine along with intrathecal bupivacaine and fentanyl on hemodynamic in lower extremity orthopedic surgery: a double-blind randomized clinical trial study. Tehran Univ Med J 2024; 82 (4) :314-322
URL: http://tumj.tums.ac.ir/article-1-13129-en.html
URL: http://tumj.tums.ac.ir/article-1-13129-en.html
Navid Kalani1 
, Hasan Zabetian2 , Shahram Shafa3 , Erfaneh Alirezai4 , Fatemeh Eftekharian5 , Reza Sahraei * 6
, Hasan Zabetian2 , Shahram Shafa3 , Erfaneh Alirezai4 , Fatemeh Eftekharian5 , Reza Sahraei * 6
1- Research Center for Social Determinants of Health, Jahrom University of Medical Sciences, Jahrom, Iran.
2- Department of Anesthesiology, Faculty of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran.
3- Department of Orthopedic Surgery, Faculty of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran.
4- Student Research Committee, Jahrom University of Medical Sciences, Jahrom, Iran.
5- Department of Internal Medicine, Faculty of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran.
6- Department of Anesthesiology, Faculty of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran. ,sahraeir1354@gmail.com
2- Department of Anesthesiology, Faculty of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran.
3- Department of Orthopedic Surgery, Faculty of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran.
4- Student Research Committee, Jahrom University of Medical Sciences, Jahrom, Iran.
5- Department of Internal Medicine, Faculty of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran.
6- Department of Anesthesiology, Faculty of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran. ,
Abstract: (64 Views)
Background: Recently, epinephrine is used to increase the depth and duration of local anesthetic pain, and it is widely used topically to reduce local anesthetic release and reduce bleeding caused by surgery.
Methods: This study was a randomized, double-blind clinical trial on 30 patients aged 18 to 85 years undergoing lower limb orthopedic surgery referred to Peymaniyeh Hospital in Jahrom from September to December 2022. Patients were randomly assigned to two groups, A (epinephrine+fentanyl+bupivacaine) and B (bupivacaine+fentanyl). Systolic blood pressure, diastolic pressure, mean arterial pressure, arterial blood oxygen saturation percentage, and pulse rate were measured and recorded before drug administration, before spinal anesthesia, after anesthesia, and then every half hour until the end of surgery (15, 45, 30, 60, 75, 90, 120) and during recovery. Data analysis was performed using SPSS version 21 software and descriptive (mean, standard deviation) and inferential statistics (t-test, chi-square, Mann-Whitney, Friedman) at a significance level of P<0.05.
Methods: This study was a randomized, double-blind clinical trial on 30 patients aged 18 to 85 years undergoing lower limb orthopedic surgery referred to Peymaniyeh Hospital in Jahrom from September to December 2022. Patients were randomly assigned to two groups, A (epinephrine+fentanyl+bupivacaine) and B (bupivacaine+fentanyl). Systolic blood pressure, diastolic pressure, mean arterial pressure, arterial blood oxygen saturation percentage, and pulse rate were measured and recorded before drug administration, before spinal anesthesia, after anesthesia, and then every half hour until the end of surgery (15, 45, 30, 60, 75, 90, 120) and during recovery. Data analysis was performed using SPSS version 21 software and descriptive (mean, standard deviation) and inferential statistics (t-test, chi-square, Mann-Whitney, Friedman) at a significance level of P<0.05.
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Results: Thirty patients aged 18 to 85 years (in two groups of 15) with anesthesia class I and II undergoing lower limb orthopedic surgery were evaluated. The study groups are matched in terms of age and gender variables. There was no significant difference in mean systolic, diastolic, mean arterial blood pressure, and heart rate before and after anesthesia, 15, 45, 30, 60, 75, 90, and 120 minutes after drug injection, and at entry and exit from recovery between the Epinephrine+Fentanyl+Bupivacaine and Fentanyl+Bupivacaine groups. There was a significant difference in mean O2SAT before anesthesia, 15, 30, and 75 minutes after drug injection between the epinephrine+fentanyl+bupivacaine and fentanyl+ bupivacaine groups (P<0.05).
Conclusion: The use of the combination of epinephrine+fentanyl+intrathecal bupivacaine compared to the combination of fentanyl+bupivacaine did not have a significant difference in the studied variables of patients' vital signs. |
Type of Study: Original Article |
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