Volume 58, Issue 2 (7 2000)
Tehran Univ Med J 2000, 58(2): 66-70 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Mirahmadian M, Rezaeei A, Nikbeen B. A study of serum ?2-microglobulin (S?2M) in hemodialysis patients with cellulosis membrane1. Tehran Univ Med J 2000; 58 (2) :66-70
URL: http://tumj.tums.ac.ir/article-1-1411-en.html
URL: http://tumj.tums.ac.ir/article-1-1411-en.html
Abstract: (5412 Views)
?2 microglobulin (?2M) fibril has been recognized as the major factor of dialysis-related amyloidosis. Elevated serum levels are thought to be the basis for tissue deposition. In order to evaluate the effect of cellulosis membrane (FB 110) and treatment duration on S?2M levels, we determined serum levels in 23 hemodialyzed patients with end-stage renal failure. S?2M levels were markedly elevated in all patients with a mean of 74.71 (SD=21.2 mg/l, range: 46 mg/l after 2 years hemodialysis-123.8 mg/l after 10 years treatment) that statistically is higher than healthy subjects (P<0.0001). Serum ?2M in 19 healthy subjects was 2.36 (SD=0.4 mg/l, rang: 1.58-3.3 mg/l). Although in hemodialysis group, no significant correlation was found between S?2M and age or sex but increased serum levels of ?2M had significant correlation with duration of hemodialysis treatment (r=0.53, P<0.01). Since the dialysis membrane has a very effective role in clearance of S?2M, we suggest that the particular effort should be made towards improvement of dialysis membranes.
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
